Selectins are multifunctional adhesion molecules that mediate the initial interactions
between circulating leukocytes and cells of the endothelium. First identified over a decade …

Selectins are multi-functional adhesion molecules that mediate the initial interactions
between circulating leukocytes and the endothelium. First identified over a decade ago …

Introduction: Selectins mediate tethering and rolling of leukocytes to the vascular
endothelium, the first adhesive step in the recruitment of immune cells to inflamed tissues …

Leukocyte emigration is essential in both lymphocyte homing, as a central part of immune
surveillance, and in leukocyte invasion at sites of inflammation. The emigration of leukocytes …

Selectins belong to a group of adhesion molecules that fulfill an essential role in immune
and inflammatory responses and tissue healing. Selectins are glycoproteins that decode the …

Inhibition of leukocyte migration into target organs has long been an attractive, though
challenging, basis for anti-inflammatory strategies. However, to date, the manipulation of …

Recent advances in our (patho) physiological understanding have underpinned the frequent
involvement of the protein family of selectins in the progression of serious illnesses …

Selectins are carbohydrate-binding molecules that bind to fucosylated and sialylated
glycoprotein ligands, and are found on endothelial cells, leukocytes and platelets. They are …

Importance of the field: Selectins play a significant and well-documented role in
inflammation and immune response. They initiate tethering and rolling of blood borne …

Characteristic features of the inflammatory and immune responses involve the recruitment of
leukocytes to sites of tissue injury and the recirculation of lymphocytes through …