Minocycline, a semisynthetic second-generation tetracycline, was reported to have
neuroprotective effects in models of global and focal cerebral ischemia, the R6/2 mouse …

Global cerebral ischemia (GCI) commonly occurs in the elderly. Subcortical white matter
lesions and oligodendrocyte (OLG) loss caused by cerebral ischemia have been implicated …

To investigate whether minocycline provides long‐lasting protection against neonatal
hypoxia–ischemia‐induced brain injury and neurobehavioral deficits, minocycline was …

Background Increasing evidence suggests that microglia experience two distinct
phenotypes after acute ischemic stroke (AIS): a deleterious M1 phenotype and a …

Recent experimental and clinical reports support the fact that the minocycline exhibits
significant neuroprotective activity in neurodegenerative diseases. However, its mechanism …

Purpose Traumatic spinal cord injury (TSCI) induces a powerful inflammatory response that
can significantly exacerbate the extent and severity of neural damage (termed as “secondary …

We investigated the protective effects of minocycline following white matter damage (WMD)
in the rat striatum. Excitotoxic lesions were induced by N-Methyl-d-Aspartate (NMDA) …

Background Compelling evidence has shown that diabetic metabolic disorder plays a critical
role in the pathogenesis of Alzheimer's disease, including increased expression of β …

Intracerebral hemorrhage (ICH) results from rupture of a blood vessel in the brain. After ICH,
the blood–brain barrier (BBB) surrounding the hematoma is disrupted, leading to cerebral …

Clinical studies examining the potential of anti-inflammatory agents, specifically of
minocycline, as a treatment for depression has shown promising results. However …