Purpose Traumatic spinal cord injury (TSCI) induces a powerful inflammatory response that
can significantly exacerbate the extent and severity of neural damage (termed as “secondary …

Mild traumatic brain injury (mTBI) represents a significant challenge for the civilian and
military health care systems due to its high prevalence and overall complexity. Our earlier …

We investigated the protective effects of minocycline following white matter damage (WMD)
in the rat striatum. Excitotoxic lesions were induced by N-Methyl-d-Aspartate (NMDA) …

Background Compelling evidence has shown that diabetic metabolic disorder plays a critical
role in the pathogenesis of Alzheimer's disease, including increased expression of β …

Clinical studies examining the potential of anti-inflammatory agents, specifically of
minocycline, as a treatment for depression has shown promising results. However …

Sphingolipids represent a major class of lipids in which selected family members act as
bioactive molecules that control diverse cellular processes, such as proliferation …

Intracerebral hemorrhage (ICH) results from rupture of a blood vessel in the brain. After ICH,
the blood–brain barrier (BBB) surrounding the hematoma is disrupted, leading to cerebral …

Hypoxic‐ischemic brain injury in the perinatal period is a major cause of morbidity and
mortality. Presently, there are no proven effective therapies with which to safeguard the …

Background Minocycline, a semi-synthetic tetracycline antibiotic, is an effective
neuroprotective agent in animal models of cerebral ischemia when given in high doses …

Depression and anxiety have been reported as the major neuropsychiatric consequences
following stroke. Minocycline, a neuroprotective drug has minimized depressive symptoms …