Simple Summary Oncolytic adenoviruses are engineered to selectively replicate in and
destroy cancer tissue. Moreover, these viruses are promising tools to restore antitumor …

The therapeutic use of viruses against cancer has been revived during the last two decades.
Oncolytic viruses replicate and spread inside tumors, amplifying their cytotoxicity and …

Introduction: Oncolytic adenoviruses are among the most studied oncolytic viruses because
of their tumor selectivity, safety, and transgene-delivery capability. With a growing number of …

Immunotherapy has moved to the forefront of modern oncologic treatment in the past few
decades. Various forms of immunotherapy currently are emerging, including oncolytic …

In this review, we discuss the use of oncolytic viruses in cancer immunotherapy treatments in
general, with a particular focus on adenoviruses. These serve as a model to elucidate how …

Simple Summary Immunotherapy has revolutionized cancer treatment, as demonstrated by
the tremendous success of checkpoint inhibitors in different tumor types. Unfortunately, most …

Adenoviruses are well characterized and thus easily modified to generate oncolytic vectors
that directly lyse tumor cells and can be" armed" with transgenes to promote lysis, antigen …

Adenoviruses (Ad) are commonly used both experimentally and clinically, including
oncolytic virotherapy applications. In the clinical area, efficacy is frequently hampered by the …

Targeted therapy of cancer using oncolytic viruses has generated much interest over the
past few years in the light of the limited efficacy and side effects of standard cancer …

Although results of cancer treatment have improved steadily, metastatic solid tumors can be
cured only rarely and therefore new modalities are needed. Tumors often become apoptosis …