Neurodegeneration precedes the onset of dementias such as Alzheimer's by several years.
Recent advances in volumetric imaging allow quantification of subtle neuroanatomical …

PURPOSE: To determine if medial temporal lobe (MTL) atrophy rate, assessed by using an
automated procedure over the initial time interval of a 6-year, three-time-point longitudinal …

Atrophy in the medial temporal lobe is generally considered to be highly associated with age-
related memory decline. Volume loss in the hippocampus and entorhinal cortex has …

Our goal was to ascertain the involvement of the temporal lobe in the preclinical (not yet
diagnosable) stages of dementia of the Alzheimer's type (DAT) by using MRI-derived …

An accurate description of changes in the brain in healthy aging is needed to understand the
basis of age-related changes in cognitive function. Cross-sectional magnetic resonance …

Magnetic resonance imaging (MRI)-based volumetric measurements of medial temporal
lobe (MTL) structures can discriminate between normal elderly control subjects and patients …

Structural brain changes have been described in both mild cognitive impairment (MCI) and
Alzheimer's disease (AD). However, less is known about whether structural changes are …

Medial temporal lobe (MTL) atrophy is a key feature of Alzheimer's disease (AD) but also
occurs in typical aging. To enhance the clinical utility of this biomarker, we need to better …

Objective To investigate the effect of age on global and regional brain volumes and rates of
atrophy, and to compare directly results based on cross-sectional and longitudinal data …

Dynamic changes in the brain's lateral ventricles on magnetic resonance imaging are
powerful biomarkers of disease progression in mild cognitive impairment (MCI) and …