Cocrystallization is an important route to tuning the solubility in drugs development,
including improving and reducing. Five cocrystals of aripiprazole (ARI) with resveratrol …

A novel co-crystal of aripiprazole (ARI), the active substance in the atypical antipsychotic
Abilify, with orcinol (ORC) as a coformer, was prepared, characterized, and compared with …

Aripiprazole (ARI) is a third-generation antipsychotic with few side effects but a poor
solubility. Salt formation, as one common form of multicomponent crystals, is an effective …

Pharmaceutical cocrystals offer a promising strategy to increase the solubility and
dissolution rate of poorly soluble drugs. However, their manufacturing process requires a …

Five novel cocrystals of antipsychotic drug aripiprazole are reported with dihydroxy-and
trihydroxybenzene coformers. The cocrystals are designed by exploiting the piperazine N …

Poor solubility and dissolution property of pharmaceuticals largely limits their bioavailability
and efficacy, and development of a multicomponent crystal is one of the effective …

Solid solutions of aripiprazole (APZ) and its active metabolite, dehydro-aripiprazole (dAPZ),
have been prepared as free form (neat or nonsolvated), hydrated, or alcohol-solvated …

We aimed to evaluate the effect of crystalline forms of aripiprazole, an antipsychotic drug for
schizophrenia, on the dissolution rates and oral pharmacokinetics. Solubility, intrinsic …

Multicomponent crystalline solid forms (salts, cocrystals and eutectics) are a promising
means of enhancing the dissolution behavior of poorly soluble drugs. The present study …

The measurement and prediction of solubilities of active pharmaceutical ingredients are
crucial in the development of polymorphism and the crystallization process. In this work, the …