The pharmaceutical cocrystal approach can be used to modify the properties of
paliperidone. We report here two novel cocrystals, paliperidone 4-hydroxybenzoic acid …

Cocrystallization of an active pharmaceutical ingredient (API) with a cocrystal former (co-
former) is widely used to tailor the physicochemical properties of parent APIs. For proton …

The aim of this study was to evaluate the effect of coprecipitation and nanomilling on the
crystallinity of a model drug, aripiprazole and evaluate the in vitro dissolution rate (IDR) …

The crystal engineering strategy was used to facilitate the supramolecular synthesis of a
new crystalline phase of iloperidone, an atypical psychotropic drug with known problems …

Olanzapine (OLZ) is a second-generation atypical anti-schizophrenia drug, and it had been
developed into various formulations, including immediate release and long-acting …

The objective of pharmaceutical cocrystallization is to create crystalline analogues that have
vastly different properties, such as solubility, melting point, stability, and bioavailability from …

Propose The propose is to investigate the reasons for the insolubility of Form III in water and
to explore the mechanism of the hydration process of Form III. Methods The conformational …

Introduction The screening of multicomponent crystal system (MCC) is a key method for
improving physicochemical properties of active pharmaceutical ingredients (APIs). The …

Aripiprazole (APZ) has poor physicochemical properties and bitter taste. The current study
aimed to prepare salts of APZ with polycarboxylic acids (citric, malic, and tartaric acids) to …

Brexpiprazole (BPZ) is an atypical antipsychotic drug indicated for the treatment of
schizophrenia and depression. Crystal form screening of BPZ resulted in the formation of …