Birth defects (congenital anomalies) are the leading cause of death in babies under 1 year
of age. Neural tube defects (NTD), with a birth incidence of approximately 1/1000 in …

Congenital defects of neural tube closure (neural tube defects; NTDs) are among the
commonest and most severe disorders of the fetus and newborn. Disturbance of any of the …

The formation of the embryonic brain and spinal cord begins as the neural plate bends to
form the neural folds, which meet and adhere to close the neural tube. The neural ectoderm …

The molecular requirements for neural tube closure are complex. This is illustrated by the
occurrence of neural tube defects (NTDs) in many genetic mouse mutants, which implicate a …

The epidemiological investigation of the common open neural tube defects (NTDs),
anencephaly, and spina bifida, has a long history. The most significant finding from these …

Neural tube defects (NTDs) are serious malformations affecting approximately 1 per 1000
births, yet the mechanisms by which they arise are unknown. There have been consistent …

Neural tube defects (NTDs) are severe congenital malformations affecting 1 in every 1000
pregnancies.'Open'NTDs result from failure of primary neurulation as seen in anencephaly …

Spina bifida, anencephaly, and encephalocele are commonly grouped together and termed
neural tube defects (NTD). Failure of closure of the neural tube during development results …

The number of mouse mutants and strains with neural tube defects (NTDs) now exceeds
240, including 205 representing specific genes, 30 for unidentified genes, and 9 …

BACKGROUND: The number of mouse mutants and strains with neural tube closure defects
(NTDs) now exceeds 190, including 155 involving known genes, 33 with unidentified genes …