Pathogenic role of complement in antiphospholipid syndrome and therapeutic implications

F Tedesco, MO Borghi, M Gerosa… - Frontiers in …, 2018 - frontiersin.org
Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by
thromboembolic events, pregnancy morbidity, and the presence of antiphospholipid (aPL) …

Is there an association between complement activation and antiphospholipid antibody-related thrombosis?

KMJ Devreese, MF Hoylaerts - Thrombosis and haemostasis, 2010 - thieme-connect.com
The antiphospholipid syndrome (APS) is a systemic autoimmune disease characterised by
arterial and/or venous thrombosis, pregnancy morbidity, and the presence of …

Complement activation in anti-phospholipid syndrome: a clue for an inflammatory process?

I Cavazzana, N Manuela, C Irene, A Barbara… - Journal of …, 2007 - Elsevier
Anti-phospholipid syndrome (APS) is defined by recurrent arterial/venous thrombosis and/or
fetal losses in the persistent presence of anti-phospholipid antibodies (aPL). In in vivo …

Complement in the pathophysiology of the antiphospholipid syndrome

S Chaturvedi, RA Brodsky, KR McCrae - Frontiers in immunology, 2019 - frontiersin.org
The antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy
morbidity in the presence of antiphospholipid antibodies (aPL). Complement is a system of …

Pathogenesis of the antiphospholipid syndrome

R Willis, EN Harris, SS Pierangeli - Seminars in thrombosis and …, 2012 - thieme-connect.com
The presence of pathogenic antiphospholipid antibodies (aPL) is the characterizing feature
of the antiphospholipid syndrome (APS), mediating the recurrent pregnancy loss and …

The journey of antiphospholipid antibodies from cellular activation to antiphospholipid syndrome

R Willis, EB Gonzalez, AR Brasier - Current Rheumatology Reports, 2015 - Springer
Pathogenic antiphospholipid antibodies (aPL) are the driving factors of recurrent pregnancy
loss and thrombosis that characterize antiphospholipid syndrome (APS). Current evidence …

New insights in the pathophysiology of antiphospholipid syndrome

A Sacharidou, PW Shaul… - Seminars in thrombosis …, 2018 - thieme-connect.com
The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by an
elevated risk for arterial and venous thrombosis and pregnancy-related morbidity. Since the …

Pathophysiology of the antiphospholipid antibody syndrome

R Willis, SS Pierangeli - Autoimmunity highlights, 2011 - Springer
Antiphospholipid antibodies (aPL) are associated with the recurrent pregnancy loss and
thrombosis that characterizes the antiphospholipid antibody syndrome (APS). Although the …

Incidence, pathophysiology, and clinical manifestations of antiphospholipid syndrome

CO Brock, AS Brohl, SG Običan - Birth Defects Research Part C …, 2015 - Wiley Online Library
Antiphospholipid syndrome (APLS) is a complex systemic disease with a wide variety of
clinical manifestations. In the obstetric population, recurrent early pregnancy loss, fetal loss …

From antibody to clinical phenotype, the black box of the antiphospholipid syndrome: pathogenic mechanisms of the antiphospholipid syndrome

VX Du, H Kelchtermans, PG de Groot, B de Laat - Thrombosis Research, 2013 - Elsevier
The antiphospholipid syndrome (APS) is diagnosed by the combination of vascular
thrombosis and/or pregnancy morbidity and the detection of antiphospholipid antibodies …