Ontogeny of diet-induced obesity in selectively bred Sprague-Dawley rats
MR Ricci, BE Levin - American Journal of Physiology …, 2003 - journals.physiology.org
Outbred Sprague-Dawley rats selectively bred for their propensity to develop diet-induced
obesity (DIO) become heavier on low-fat diet than those bred to be diet resistant (DR) …
obesity (DIO) become heavier on low-fat diet than those bred to be diet resistant (DR) …
Defense of differfing body weight set points in diet-induced obese and resistant rats
Among outbred Sprague-Dawley rats, approximately one-half develop diet-induced obesity
(DIO) and one-half are diet resistant (DR) on a diet relatively high in fat and energy content …
(DIO) and one-half are diet resistant (DR) on a diet relatively high in fat and energy content …
Maternal obesity increases hypothalamic leptin receptor expression and sensitivity in juvenile obesity-prone rats
JN Gorski, AA Dunn-Meynell… - American Journal of …, 2007 - journals.physiology.org
In rats selectively bred to develop diet-induced obesity (DIO) or to be diet-resistant (DR), DIO
maternal obesity selectively enhances the development of obesity and insulin resistance in …
maternal obesity selectively enhances the development of obesity and insulin resistance in …
A new obesity-prone, glucose-intolerant rat strain (F. DIO)
BE Levin, AA Dunn-Meynell… - American Journal …, 2003 - journals.physiology.org
Previous breeding for the diet-induced obese (DIO) trait from outbred Sprague-Dawley rats
produced a substrain with selection characteristics suggesting a polygenic mode of …
produced a substrain with selection characteristics suggesting a polygenic mode of …
Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats
BE Levin, AA Dunn-Meynell… - American Journal of …, 1997 - journals.physiology.org
In outbred Sprague-Dawley rats, about one-half develop diet-induced obesity (DIO) on a diet
relatively high in fat and energy (HE diet). The rest are diet resistant (DR), gaining weight …
relatively high in fat and energy (HE diet). The rest are diet resistant (DR), gaining weight …
Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset
BE Levin, AA Dunn-Meynell… - American Journal of …, 2004 - journals.physiology.org
Rats selectively bred to develop diet-induced obesity (DIO) were compared with those bred
to be diet resistant (DR) on a 31% fat high-energy diet with regard to their central leptin …
to be diet resistant (DR) on a 31% fat high-energy diet with regard to their central leptin …
Large litter rearing enhances leptin sensitivity and protects selectively bred diet-induced obese rats from becoming obese
CM Patterson, SG Bouret, S Park, BG Irani… - …, 2010 - academic.oup.com
Because rearing rats in large litters (LLs) protects them from becoming obese, we postulated
that LL rearing would protect rats selectively bred to develop diet-induced obesity (DIO) from …
that LL rearing would protect rats selectively bred to develop diet-induced obesity (DIO) from …
Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling
CM Patterson, SG Bouret… - American Journal of …, 2009 - journals.physiology.org
In rats selectively bred to develop diet-induced obesity (DIO) 3 wk of postweaning exercise
reduces weight and adipose regain for 10 wk after exercise cessation, despite intake of 31 …
reduces weight and adipose regain for 10 wk after exercise cessation, despite intake of 31 …
Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats
BE Levin, AA Dunn-Meynell… - American Journal of …, 2003 - journals.physiology.org
Rats selectively bred to develop diet-induced obesity (DIO) spontaneously gain more body
weight between 5 and 7 wk of age than do those bred to be diet resistant (DR). Here, chow …
weight between 5 and 7 wk of age than do those bred to be diet resistant (DR). Here, chow …
Defense of body weight against chronic caloric restriction in obesity-prone and-resistant rats
BE Levin, AA Dunn-Meynell - American Journal of …, 2000 - journals.physiology.org
Half of Sprague-Dawley rats develop and defend diet-induced obesity (DIO) or diet
resistance (DR) when fed a high-energy (HE) diet. Here, adult male rats were made DIO or …
resistance (DR) when fed a high-energy (HE) diet. Here, adult male rats were made DIO or …