▪ Abstract Disease prevention is one area that both public and governmental agencies
strongly support owing to its potential for an improved lifestyle and a reduction in health care …

An expanding body of evidence indicates that downregulation of the cy-clooxygenases (Cox-
1 and Cox-2) will be an important strategy for preventing cancer because cyclooxygenases …

Abstract Cyclooxygenase‐2 (COX‐2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. A …

Two events in the last decade have set the stage for the large-scale clinical testing of
chemopreventive agents for colorectal cancer in people at low to moderate risk for this …

Cyclooxygenase (COX), a key enzyme in the prostanoid biosynthetic pathway, has received
considerable attention due to its role in human cancers. Observational and randomized …

Abstract Cyclooxygenase2 (COX-2), an inducible prostaglandin G/H synthase, is
overexpressed in several human cancers. Here, the potential utility of selective COX-2 …

Evidence derived from several lines of investigation suggest that prostaglandins,
metabolites of arachidonic acid, play an important role in colon cancer development …

Metabolites of arachidonic acid participate in normal growth responses and in aberrant
cellular growth and proliferation, including carcinogenesis. The key step in the conversion of …

Cyclooxygenase (COX), the key regulatory enzyme for prostaglandin synthesis, is
transcribed from two distinct genes. COX-1 is expressed constitutively in most tissues …

Cyclooxygenase-2 (COX-2) is being intensively evaluated as a pharmacologic target for
both the prevention and treatment of cancer. Aberrant COX-2 expression was initially …