The cyclooxygenase-2 (COX-2) enzyme has a fundamental role in the carcinogenesis of
colorectal cancer. The anticarcinogenic mechanisms of NSAIDs are not completely …

Understanding the mechanisms underlying carcinogenesis provides insights that are
necessary for the development of therapeutic strategies to prevent cancer …

Epidemiological and experimental studies have demonstrated the effect of non-steroidal anti-
inflammatory drugs (NSAIDs) in the prevention of human cancers. NSAIDs block …

Mortality in patients with advanced colorectal cancer (CRC) remains high. Epidemiologic
studies show that individuals taking nonselective, nonsteroidal anti-inflammatory drugs …

Abstract Cyclooxygenase 2 (COX-2), also called prostaglandin endoperoxide synthase 2, is
involved in colorectal tumor development. This review deals with particular questions raised …

Abstract Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers …

Several lines of evidence suggest that cyclooxygenase-2 (COX-2) is a rational target for
anticancer therapy. Epidemiological studies have shown that use of nonsteroidal anti …

Chronic inflammation is a tissue-specific process implicated in several diseases of an aging
population, including cancer, cardiovascular disease, and arthritis. Cyclooxygenase-2 (COX …

Epidemiologic studies have documented a 40–50% reduction in incidence of colorectal
cancer in individuals taking nonsteroidal antiinflammatory drugs (NSAIDs). Since NSAIDs …

Background Epidemiologic and laboratory investigations suggest that aspirin and other
nonsteroidal anti-inflammatory drugs (NSAIDs) have chemopreventive effects against colon …