COX selectivity and animal models for colon cancer
M Oshima, MM Taketo - Current pharmaceutical design, 2002 - ingentaconnect.com
Early experiments performed during 1980s and 1990s using carcinogen-induced rat
intestinal tumor models demonstrated the inhibitory effects of non-steroidal anti-inflammatory …
intestinal tumor models demonstrated the inhibitory effects of non-steroidal anti-inflammatory …
Cyclooxygenase, NSAIDs, and colorectal cancer
RN DuBois, WE Smalley - Journal of gastroenterology, 1996 - Springer
Prevention of human diseases has become a major focus of biomedical investigators
around the world. Our current screening and treatment regimens for colorectal cancer are …
around the world. Our current screening and treatment regimens for colorectal cancer are …
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
CE Eberhart, RJ Coffey, A Radhika, FM Giardiello… - Gastroenterology, 1994 - Elsevier
Abstract Background/Aims: Several clinical, epidemiological, and animal studies indicate
that nonsteroidal anti-inflammatory drugs (NSAIDs) may alter the incidence of colorectal …
that nonsteroidal anti-inflammatory drugs (NSAIDs) may alter the incidence of colorectal …
Targeting COX-2 expression by natural compounds: a promising alternative strategy to synthetic COX-2 inhibitors for cancer chemoprevention and therapy
Cyclooxygenase (COX)-2 is a pro-inflammatory immediate early response protein,
chronically up-regulated in many pathological conditions. In autoimmune diseases, it is …
chronically up-regulated in many pathological conditions. In autoimmune diseases, it is …
Cancer chemoprevention through interruption of multistage carcinogenesis: the lessons learnt by comparing mouse skin carcinogenesis and human large bowel …
F Marks, G Fürstenberger - European Journal of Cancer, 2000 - Elsevier
Whilst in the early stages, neoplastic development is predominantly triggered by
environmental genotoxic and non-genotoxic carcinogens, tumour progression becomes …
environmental genotoxic and non-genotoxic carcinogens, tumour progression becomes …
A cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug enhances the growth inhibitory effect of butyrate in colorectal carcinoma cells expressing …
TE Crew, DJE Elder, C Paraskeva - Carcinogenesis, 2000 - academic.oup.com
Epidemiological, clinical, animal and laboratory studies have all provided evidence for the
protective effects of non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin, against …
protective effects of non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin, against …
Mechanistic aspects of COX-2 expression in colorectal neoplasia
Abstract The cyclooxygenase-2 (COX-2) enzyme catalyzes the rate-limiting step of
prostaglandin formation in pathogenic states and a large amount of evidence has …
prostaglandin formation in pathogenic states and a large amount of evidence has …
Cyclooxygenase 2-derived prostaglandin E2 regulates the angiogenic switch
D Wang, RN DuBois - … of the National Academy of Sciences, 2004 - National Acad Sciences
The first evidence of a potential relationship between the cycloox-ygenase 2 (COX-2)
enzyme and human cancers was reported in 1994, when COX-2 mRNA levels were found to …
enzyme and human cancers was reported in 1994, when COX-2 mRNA levels were found to …