[HTML][HTML] Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse …
To characterize the mutational patterns of acute lymphoblastic leukemia (ALL) we performed
deep next generation sequencing of 872 cancer genes in 172 diagnostic and 24 relapse …
deep next generation sequencing of 872 cancer genes in 172 diagnostic and 24 relapse …
Mutational landscape of pediatric acute lymphoblastic leukemia
Current standard of care for patients with pediatric acute lymphoblastic leukemia (ALL) is
mainly effective, with high remission rates after treatment. However, the genetic …
mainly effective, with high remission rates after treatment. However, the genetic …
Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia
H Ueno, K Yoshida, Y Shiozawa, Y Nannya… - Blood …, 2020 - ashpublications.org
Recent genetic studies using high-throughput sequencing have disclosed genetic
alterations in B-cell precursor acute lymphoblastic leukemia (B-ALL). However, their effects …
alterations in B-cell precursor acute lymphoblastic leukemia (B-ALL). However, their effects …
Genetic mutational analysis of pediatric acute lymphoblastic leukemia from a single center in China using exon sequencing
H Zhang, H Wang, X Qian, S Gao, J Xia, J Liu, Y Cheng… - BMC cancer, 2020 - Springer
Background Acute lymphoblastic leukemia (ALL), the most common childhood malignancy,
is characterized by recurring structural chromosomal alterations and genetic alterations …
is characterized by recurring structural chromosomal alterations and genetic alterations …
Genetic drivers of vulnerability and resistance in relapsed acute lymphoblastic leukemia
SX Lu, O Abdel-Wahab - Proceedings of the National …, 2016 - National Acad Sciences
Relapsed acute lymphoblastic leukemia (ALL) is associated with very poor outcomes
despite modern therapies in both children and adults (1–3). In PNAS, Oshima et al. elucidate …
despite modern therapies in both children and adults (1–3). In PNAS, Oshima et al. elucidate …
The genomic landscape of pediatric acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using
whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL …
whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL …
Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemia
Childhood B-cell acute lymphoblastic leukaemia (B-ALL) is characterised by recurrent
genetic abnormalities that drive risk-directed treatment strategies. Using current techniques …
genetic abnormalities that drive risk-directed treatment strategies. Using current techniques …
Comprehensive genome characterization of childhood T-ALL links oncogene activation mechanism and subtypes to prognosis
P Pölönen, A Elsayed, D Di Giacomo, L Montefiori… - Blood, 2022 - ashpublications.org
Background: Children with relapsed T-cell acute lymphoblastic leukemia (T-ALL) have poor
prognosis, and identification of patients at risk for recurrence is required to prevent relapse …
prognosis, and identification of patients at risk for recurrence is required to prevent relapse …
Panel-based next-generation sequencing identifies prognostic and actionable genes in childhood acute lymphoblastic leukemia and is suitable for clinical sequencing
H Ishida, A Iguchi, M Aoe, T Takahashi, K Tamefusa… - Annals of …, 2019 - Springer
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Although
the cure rate of ALL has greatly improved, a considerable number of patients suffer from …
the cure rate of ALL has greatly improved, a considerable number of patients suffer from …
Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia
The underlying pathways that lead to relapse in childhood acute lymphoblastic leukemia
(ALL) are unknown. To comprehensively characterize the molecular evolution of relapsed …
(ALL) are unknown. To comprehensively characterize the molecular evolution of relapsed …