[HTML][HTML] Peroxisome proliferator-activated receptors gama ameliorates liver fibrosis in non-alcoholic fatty liver disease by inhibiting TGF-β/Smad signaling activation
Q Zhang, W Zhao, Z Sun, X Dong, L Zhu… - Frigid Zone …, 2024 - degruyter.com
Background Nonalcoholic fatty liver disease (NAFLD) is a chronic condition characterized by
a progressive decline in liver function, leading to disruptions in liver integrity and metabolic …
a progressive decline in liver function, leading to disruptions in liver integrity and metabolic …
PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets
H Chen, H Tan, J Wan, Y Zeng, J Wang… - Pharmacology & …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …
disease, has emerged as a major public health problem, more efficient therapeutics of which …
Revealing the role of peroxisome proliferator-activated receptor β/δ in nonalcoholic fatty liver disease
M Zarei, D Aguilar-Recarte, X Palomer… - Metabolism, 2021 - Elsevier
Nonalcoholic fatty liver disease (NAFLD), a form of chronic liver disease that occurs in
individuals with no significant alcohol abuse, has become an increasing concern for global …
individuals with no significant alcohol abuse, has become an increasing concern for global …
[HTML][HTML] Insights into the Role of PPARβ/δ in NAFLD
Non-alcoholic fatty liver disease (NAFLD) is a major health issue in developed countries.
Although usually associated with obesity, NAFLD is also diagnosed in individuals with low …
Although usually associated with obesity, NAFLD is also diagnosed in individuals with low …
Roles of PPARs in NAFLD: potential therapeutic targets
Non-alcoholic fatty liver disease (NAFLD) is a liver pathology with increasing prevalence
due to the obesity epidemic. Hence, NAFLD represents a rising threat to public health …
due to the obesity epidemic. Hence, NAFLD represents a rising threat to public health …
Curative role of natural PPARγ agonist in non-alcoholic fatty liver disease (NAFLD)
ABSTRACT NAFLD is a condition that develops when the liver accumulates excess fat
without alcohol consumption. This chronic liver ailment progresses along with insulin …
without alcohol consumption. This chronic liver ailment progresses along with insulin …
[HTML][HTML] Hepatocyte-specific loss of PPARγ protects mice from NASH and increases the therapeutic effects of rosiglitazone in the liver
SM Lee, CM Pusec, GH Norris, A De Jesus… - Cellular and molecular …, 2021 - Elsevier
Background & Aims Nonalcoholic steatohepatitis (NASH) is commonly observed in patients
with type 2 diabetes, and thiazolidinediones (TZD) are considered a potential therapy for …
with type 2 diabetes, and thiazolidinediones (TZD) are considered a potential therapy for …
[HTML][HTML] Peroxisome proliferator-activated receptors as targets to treat non-alcoholic fatty liver disease
V Souza-Mello - World journal of hepatology, 2015 - ncbi.nlm.nih.gov
Lately, the world has faced tremendous progress in the understanding of non-alcoholic fatty
liver disease (NAFLD) pathogenesis due to rising obesity rates. Peroxisome proliferator …
liver disease (NAFLD) pathogenesis due to rising obesity rates. Peroxisome proliferator …
[HTML][HTML] Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content
Y Sasaki, M Asahiyama, T Tanaka, S Yamamoto… - Scientific Reports, 2020 - nature.com
Non-alcoholic steatohepatitis (NASH) is characterized by macrovesicular steatosis with
ballooning degeneration of hepatocytes, diffused lobular inflammation, and fibrosis. PPAR …
ballooning degeneration of hepatocytes, diffused lobular inflammation, and fibrosis. PPAR …
The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and strongly associated
with central obesity, dyslipidemia, and insulin resistance. According to the multiple-hit model …
with central obesity, dyslipidemia, and insulin resistance. According to the multiple-hit model …