[HTML][HTML] Peroxisome proliferator-activated receptors gama ameliorates liver fibrosis in non-alcoholic fatty liver disease by inhibiting TGF-β/Smad signaling activation

Q Zhang, W Zhao, Z Sun, X Dong, L Zhu… - Frigid Zone …, 2024 - degruyter.com
Background Nonalcoholic fatty liver disease (NAFLD) is a chronic condition characterized by
a progressive decline in liver function, leading to disruptions in liver integrity and metabolic …

PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets

H Chen, H Tan, J Wan, Y Zeng, J Wang… - Pharmacology & …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …

Revealing the role of peroxisome proliferator-activated receptor β/δ in nonalcoholic fatty liver disease

M Zarei, D Aguilar-Recarte, X Palomer… - Metabolism, 2021 - Elsevier
Nonalcoholic fatty liver disease (NAFLD), a form of chronic liver disease that occurs in
individuals with no significant alcohol abuse, has become an increasing concern for global …

[HTML][HTML] Insights into the Role of PPARβ/δ in NAFLD

J Chen, A Montagner, NS Tan, W Wahli - International journal of …, 2018 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a major health issue in developed countries.
Although usually associated with obesity, NAFLD is also diagnosed in individuals with low …

Roles of PPARs in NAFLD: potential therapeutic targets

A Tailleux, K Wouters, B Staels - … et Biophysica Acta (BBA)-Molecular and …, 2012 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a liver pathology with increasing prevalence
due to the obesity epidemic. Hence, NAFLD represents a rising threat to public health …

Curative role of natural PPARγ agonist in non-alcoholic fatty liver disease (NAFLD)

S Singh, A Kumar, S Gupta, R Agrawal - Tissue Barriers, 2023 - Taylor & Francis
ABSTRACT NAFLD is a condition that develops when the liver accumulates excess fat
without alcohol consumption. This chronic liver ailment progresses along with insulin …

[HTML][HTML] Hepatocyte-specific loss of PPARγ protects mice from NASH and increases the therapeutic effects of rosiglitazone in the liver

SM Lee, CM Pusec, GH Norris, A De Jesus… - Cellular and molecular …, 2021 - Elsevier
Background & Aims Nonalcoholic steatohepatitis (NASH) is commonly observed in patients
with type 2 diabetes, and thiazolidinediones (TZD) are considered a potential therapy for …

[HTML][HTML] Peroxisome proliferator-activated receptors as targets to treat non-alcoholic fatty liver disease

V Souza-Mello - World journal of hepatology, 2015 - ncbi.nlm.nih.gov
Lately, the world has faced tremendous progress in the understanding of non-alcoholic fatty
liver disease (NAFLD) pathogenesis due to rising obesity rates. Peroxisome proliferator …

[HTML][HTML] Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content

Y Sasaki, M Asahiyama, T Tanaka, S Yamamoto… - Scientific Reports, 2020 - nature.com
Non-alcoholic steatohepatitis (NASH) is characterized by macrovesicular steatosis with
ballooning degeneration of hepatocytes, diffused lobular inflammation, and fibrosis. PPAR …

The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice

M Pawlak, E Baugé, W Bourguet, K De Bosscher… - Hepatology, 2014 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and strongly associated
with central obesity, dyslipidemia, and insulin resistance. According to the multiple-hit model …