Abnormal natural killer cytotoxicity in primary biliary cirrhosis: evidence for a functional deficiency of cytolytic effector cells

SP James, EA Jones - Gastroenterology, 1985 - Elsevier
The in vitro cytotoxic activity of peripheral blood lymphocytes from patients with primary
biliary cirrhosis was investigated to determine the mechanism of deficient spontaneous cell …

Natural killer-cell activity and the response to interferons α, β, and γ in patients with primary biliary cirrhosis

DS Matheson, BJ Green, GY Minuk - Journal of allergy and clinical …, 1989 - Elsevier
Primary biliary cirrhosis (PBC) is a chronic, life-threatening disorder that is believed to be
immunologically mediated. Abnormal immunologic findings have been detected in T …

[PDF][PDF] Phenotypic and functional characteristics of lymphocytes isolated from liver biopsy specimens from patients with active liver disease

K Hata, DH van Thiel, RB Herberman… - Hepatology, 1992 - Wiley Online Library
Liver‐derived lymphocytes were isolated from 73 liver biopsy specimens obtained from
patients with chronic active liver disease and from six samples of normal liver. Mean …

Natural killer activity of human liver-derived lymphocytes in various liver diseases

K Hata, DH van Thiel, RB Herberman, TL Whiteside - Hepatology, 1991 - journals.lww.com
Liver-derived lymphocytes were isolated from 40 human livers with end-stage liver disease
that were removed at the time of orthotopic liver transplantation. In addition, 10 resection …

Natural killer and activated killer activities in chronic liver disease and hepatocellular carcinoma: evidence for a decreased lymphokine-induced activity of effector cells …

H Hirofuji, S Kakumu, A Fuji, Y Ohtani… - Clinical and …, 1987 - ncbi.nlm.nih.gov
Natural killer (NK) and activated killer (AK) cells appear to be important in
immunoregulation, elimination of virus-infected cells and resistance to tumours. NK activity …

Propagation and characterization of lymphocytes infiltratiti livers of patients with primary biliary cirrhosis and autoimmune hepatitis

SL Saidman, AJ Demetris, A Zeevi, RJ Duquesnoy - Human Immunology, 1990 - Elsevier
Lymphocytes were prolagated with interleukin 2 from liver tissue removed at transplantation
from patients with primary biliary cirrhosis or autoimmune chronic active hepatitis …

In vitro cell-mediated cytotoxicity in primary biliary cirrhosis and chronic hepatitis. Dysfunction of spontaneous cell-mediated cytotoxicity in primary biliary cirrhosis.

JM Vierling, DL Nelson, W Strober… - The Journal of …, 1977 - Am Soc Clin Investig
The in vitro cytotoxic function and target cell specificity of peripheral blood lymphocytes from
selected patients with primary biliary cirrhosis and hepatitis B surface antigen-negative …

Natural killer activity in patients with biopsy-proven liver disease.

S Serdengecti, DB Jones, G Holdstock… - Clinical and …, 1981 - ncbi.nlm.nih.gov
Most previous studies of lymphocyte-mediated cytotoxicity to animal and human hepatocytes
have not taken into account the ability to human lymphoid cells to kill spontaneously cultured …

Depressed lymphokine-activated killer activity and analysis of the precursor cells in peripheral blood of patients with hepatocellular carcinoma.

M Shirai, S Watanabe, M Nishioka - Hepato-gastroenterology, 1990 - europepmc.org
The in vitro lymphokine-activated killer activity and natural killer activity of peripheral blood
mononuclear cells from 33 patients with hepatocellular carcinoma were investigated …

The role of natural killer cells and lymphokine activated killer cells in the pathogenesis of hepatic injury in hepatitis A [corrected].

M Baba, K Fukai, H Hasegawa… - Journal of clinical & …, 1992 - europepmc.org
In order to clarify the mechanism of liver damage in hepatitis A, we studied the role of
Natural Killer (NK) cells and Lymphokine Activated Killer (LAK) cells in non-specific …