The detection, stabilization, and repair of stress-induced damage are essential requirements
for cellular life. All cells respond to osmotic stress-induced water loss with increased …

Exposure of C. elegans to hypertonic stress-induced water loss causes rapid and
widespread cellular protein damage. Survival in hypertonic environments depends critically …

The damaging effects of hypertonic stress on cellular proteins are poorly defined, and almost
nothing is known about the pathways that detect and repair hypertonicity-induced protein …

In mammals, the cells of the renal medulla are physiologically exposed to interstitial
osmolalities several-fold higher that found in any other tissue. Nevertheless, these cells not …

Proteostasis is defined as the homeostatic mechanisms that maintain the function of all
cytoplasmic proteins. We recently demonstrated that the capacity of the proteostasis network …

When exposed to increased dissolved solute in their environment (hyperosmotic stress), all
eukaryotic cells respond by rapidly activating a conserved mitogen-activated protein kinase …

Protein damage contributes prominently to cellular aging. To address whether this occurs at
a specific period during aging or accumulates gradually, we monitored the biochemical …

The ability to control osmotic balance is essential for cellular life. Cellular osmotic
homeostasis is maintained by accumulation and loss of inorganic ions and organic …

Organisms exposed to the damaging effects of high osmolarity accumulate solutes to
increase cytoplasmic osmolarity. Yeast accumulates glycerol in response to osmotic stress …

A hallmark of diseases of protein conformation and aging is the appearance of protein
aggregates associated with cellular toxicity. We posit that the functional properties of the …