Triple-negative breast cancer (TNBC) is the most difficult breast cancer subtype to treat due
to the lack of targeted therapies. Cancer stem cells (CSCs) are strongly enriched in TNBC …

Triple-negative breast cancers (TNBCs) are characterized by high rates of recurrence and
poor clinical outcomes. Deregulated E3 ligases are involved in breast cancer pathogenesis …

The development of triple-negative breast cancer (TNBC) negatively impacts both quality of
life and survival in a high percentage of patients. Here, we show that RING finger protein …

The HER2-positive breast cancer subtype (HER2+-BC) displays a particularly aggressive
behavior. Anti-HER2 therapies have significantly improved the survival of patients with …

Background Recently genome-based studies revealed that the abnormality of Hippo
signaling is pervasive in TNBC and played important role in cancer progression. RING finger …

Breast cancer subtypes display distinct biological traits that influence their clinical behavior
and response to therapy. Recent studies have highlighted the importance of chromatin …

Ring finger protein 144A (RNF144A), a poorly characterized member of the RING-in-
between-RING family of E3 ubiquitin ligases, is an emerging tumor suppressor, but its …

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a
high risk of metastasis and recurrence. Although chemotherapy has greatly improved the …

Background Triple-negative breast cancer (TNBC) remains the most challenging subtype of
breast cancer and lacks definite treatment targets. Aerobic glycolysis is a hallmark of …

Background The transcriptional repressor B-cell lymphoma 6 (BCL6) is dysregulated in
several neoplasms, but its role in triple negative breast cancer (TNBC), a highly aggressive …