Impact of tau on neurovascular pathology in Alzheimer's disease

E Canepa, S Fossati - Frontiers in neurology, 2021 - frontiersin.org
Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most prevalent
cause of dementia. The main cerebral histological hallmarks are represented by …

Neurovascular dysfunction and vascular amyloid accumulation as early events in Alzheimer's disease

R Apátiga-Pérez, LO Soto-Rojas… - Metabolic brain …, 2022 - Springer
Alzheimer's disease (AD) is clinically characterized by a progressive loss of cognitive
functions and short-term memory. AD patients present two distinctive neuropathological …

Alzheimer's disease, cerebrovascular disease, and the β-amyloid cascade

K Honjo, SE Black, NPLG Verhoeff - Canadian Journal of …, 2012 - cambridge.org
Alzheimer's disease (AD), considered the commonest neurodegenerative cause of
dementia, is associated with hallmark pathologies including extracellular amyloid-β protein …

Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer's disease

Z Hoglund, N Ruiz-Uribe, E Del Sastre, B Woost… - Acta …, 2024 - Springer
Insoluble pathogenic proteins accumulate along blood vessels in conditions of cerebral
amyloid angiopathy (CAA), exerting a toxic effect on vascular cells and impacting cerebral …

The neurovascular unit dysfunction in Alzheimer's disease

LO Soto-Rojas, M Pacheco-Herrero… - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide.
Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and …

The amyloid-tau-neuroinflammation axis in the context of cerebral amyloid angiopathy

P Cisternas, X Taylor… - International journal of …, 2019 - mdpi.com
Cerebral amyloid angiopathy (CAA) is typified by the cerebrovascular deposition of amyloid.
Currently, there is no clear understanding of the mechanisms underlying the contribution of …

[HTML][HTML] Cerebral microvascular accumulation of tau oligomers in Alzheimer's disease and related tauopathies

DL Castillo-Carranza, AN Nilson, CE Van Skike… - Aging and …, 2017 - ncbi.nlm.nih.gov
The importance of vascular contributions to cognitive impairment and dementia (VCID)
associated with Alzheimer's disease (AD) and related neurodegenerative diseases is …

Progression of Alzheimer's disease, tau propagation, and its modifiable risk factors

S Takeda - Neuroscience research, 2019 - Elsevier
The number of patients with Alzheimer's disease (AD) has been increasing exponentially
side by side with aging societies worldwide. Symptoms of AD worsen over time due to …

Tau as a mediator of neurotoxicity associated to cerebral amyloid angiopathy

Y You, A Perkins, P Cisternas, B Muñoz… - Acta neuropathologica …, 2019 - Springer
Cerebral amyloid angiopathy (CAA) is typified by the cerebrovascular deposition of amyloid.
Currently, there is no clear understanding of the mechanisms underlying the contribution of …

Dissecting the contribution of vascular alterations and aging to Alzheimer's disease

C Janota, CA Lemere, MA Brito - Molecular neurobiology, 2016 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline
that afflicts as many as 45% of individuals who survive past the age of 85. AD has been …