In endothelial cells, the AMP-activated protein kinase (AMPK) is stimulated by sheer stress
or growth factors that stimulate release of nitric oxide (NO). We hypothesized that NO might …

Recent studies have indicated that endothelial nitric-oxide synthase (eNOS) is regulated by
reversible phosphorylation in intact endothelial cells. AMP-activated protein kinase (AMPK) …

We previously reported the phosphoinositide 3-kinase-dependent activation of the 5′-AMP-
activated kinase (AMPK) by peroxynitrite (ONOO-) and hypoxia-reoxygenation in cultured …

Hydrogen peroxide and other reactive oxygen species are intimately involved in endothelial
cell signaling. In many cell types, the AMP-activated protein kinase (AMPK) has been …

AMP-activated protein kinase (AMPK) is a sensor of cellular energy state and a regulator of
cellular homeostasis. In endothelial cells, AMPK is stimulated via the upstream kinases …

AMP-activated protein kinase (AMPK) is frequently reported to phosphorylate Ser1177 of the
endothelial nitric-oxide synthase (eNOS), and therefore, is linked with a relaxing effect …

The endothelial isoform of nitric-oxide synthase (eNOS), a key determinant of vascular
homeostasis, is a calcium/calmodulin-dependent phosphoprotein regulated by diverse cell …

Reports on the role of AMP-activated protein kinase (AMPK) in thrombin-mediated activation
of endothelial nitric-oxide synthase (eNOS) in endothelial cells have been conflicting …

Objective—The regulation of AMP-activated protein kinase (AMPK) is implicated in vascular
biology because AMPK can phosphorylate endothelial NO synthase (eNOS). In this study …

The AMP-activated protein kinase (AMPK) was initially identified as the kinase that
phosphorylates the 3-hydroxy 3-methylglutaryl coenzyme A reductase, the rate-limiting …