The reaction of xanthine and xanthine oxidase generates superoxide and hydrogen
peroxide. In contrast to earlier works, recent spin trapping data (Kuppusamy, P., and Zweier …

Xanthine dehydrogenases from various sources are proteins of molecular mass 300 kDa
and are composed of two identical independent subunits; each subunit contains one …

Previous studies have proposed and supported a role for the proteolytic, irreversible
conversion of xanthine dehydrogenase to xanthine oxidase (XO) in postischemic injury in a …

The generation of oxidants in reperfused ischemic tissues by xanthine oxidase (XO) may
contribute to tissue damage. We exposed bovine pulmonary microvascular endothelial …

Oxygen metabolites have been implicated in the pathogenesis of various types of acute
tissue injury. One biologic source of oxygen metabolites is the reaction catalyzed by the …

Oxidative damage is believed to cause reperfusion injury in tissues. It is presumed that
xanthine oxidase (acting on hypoxanthine released by ATP depletion) is the main source of …

Thrombolytic therapy has gained widespread acceplance as a means of treating coronary
artery thrombosis in patients with acute myocardial infarction. Although experimental data …

The enzyme xanthine oxidase (XO) has been implicated in the pathogenesis of several
disease processes, such as ischemia-reperfusion injury, because of its ability to generate …

Anacardic acid, 6 [8 (Z), 11 (Z), 14-pentadecatrienyl] salicylic acid, inhibits generation of
superoxide radicals by xanthine oxidase. This inhibition does not follow a hyperbolic …

Human xanthine oxidase was purified from breast milk. The dehydrogenase form of the
enzyme, which predominates in most mammalian tissues, catalyses the oxidation of NADH …