Simple, high-yield purification of xanthine oxidase from bovine milk

N Özer, M Müftüoglu, D Ataman, A Ercan… - Journal of biochemical …, 1999 - Elsevier
Xanthine oxidase, a commercially important enzyme with a wide area of application, was
extracted from fresh milk, without added preservatives, using toluene and heat. The short …

Endogenous xanthine oxidase does not significantly contribute to vascular endothelial production of reactive oxygen species

A Palermartinez, PC Panus, PH Chumley… - Archives of biochemistry …, 1994 - Elsevier
The contribution of xanthine oxidoreductase (XDH+ XO) to the extracellular release of
hydrogen peroxide (H 2 O 2) and intracellular H 2 O 2 concentration in cultured bovine aortic …

The conversion of xanthine dehydrogenase to xanthine oxidase and the role of the enzyme in reperfusion injury

T Nishino - The Journal of Biochemistry, 1994 - academic.oup.com
Although mammalian xanthine oxidase exists originally as a dehydrogenase form in freshly
prepared samples, it is converted to an oxidase form during purification, either irreversibly by …

Xanthine oxidase produces O2-. in posthypoxic injury of renal epithelial cells

EL Greene, MS Paller - American Journal of Physiology …, 1992 - journals.physiology.org
The hypothesis that posthypoxic renal injury is mediated by xanthine oxidase-derived
oxygen free radical production was tested in an in vitro model of rat proximal tubule …

The contribution of vascular endothelial xanthine dehydrogenase/oxidase to oxygen-mediated cell injury

PC Panus, SA Wright, PH Chumley, R Radi… - Archives of biochemistry …, 1992 - Elsevier
The conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) and the
reaction of XO-derived partially reduced oxygen species (PROS) have been suggested to be …

Role of xanthine oxidase in reperfusion injury of ischemic skeletal muscles in the pig and human

D Dorion, A Zhong, C Chiu… - Journal of applied …, 1993 - journals.physiology.org
We investigated whether xanthine oxidase (XO) is a major source of oxygen-derived free
radicals (oxy-radicals) in the pig and human skeletal muscles. It was observed that xanthine …

Superoxide radical and xanthine oxidoreductase activity in the human heart during cardiac operations

SW MacGowan, MC Regan, C Malone… - The Annals of thoracic …, 1995 - Elsevier
BACKGROUND.: The results of clinical trials of xanthine oxidoreductase inhibition in cardiac
surgery are encouraging, although studies have failed to localize the enzyme to the human …

Molecular activation—deactivation of xanthine oxidase in human milk

AM Brown, M Benboubetra, M Ellison, D Powell… - … et Biophysica Acta (BBA …, 1995 - Elsevier
Enzymic activity and protein levels of xanthine oxidase were measured in serial samples of
breast milk donated by each of 14 mothers, starting, in all but two cases, within 7 days …

Physiological roles of xanthine oxidoreductase

R Harrison - Drug metabolism reviews, 2004 - Taylor & Francis
Xanthine oxidoreductase (XOR) is a major protein component of the milk fat globule
membrane (MFGM) surrounding fat droplets in milk and its enzymology is well …

Reaction of xanthine oxidase-derived oxidants with lipid and protein of human plasma

R Radi, KM Bush, TP Cosgrove, BA Freeman - Archives of biochemistry …, 1991 - Elsevier
Xanthine oxidase and purines have recently been detected in the circulation during acute
viral infection and following hepatotoxicity and shock. Reactions of xanthine oxidase …