Venous blood levels of angiotensin I, angiotensin II, bradykinin and renin were measured
before, and 30, 60, 90 and 120 minutes after, the administration of Captopril (50 mg) to eight …

1. The effects of a single 25 mg oral dose of captopril on blood pressure, heart rate and
circulating renin, angiotensin I, angiotensin II, bradykinin and catecholamine levels were …

Captopril (SQ 14225), a new orally acting angiotensin‐converting enzyme (kininase II)
inhibitor, was administered by gavage to normal Sprague‐Dawley rats in doses of 1 mg/kg …

Captopril (SQ 14225) or hydrochlorothiazide was given to a group of 20 patients with
essential hypertension for four weeks, followed by eight weeks' therapy with both drugs …

1 The ability of captopril, 150 mg three times daily by mouth, to effect sustained reduction in
plasma angiotensin II, with converse increases in circulating angiotensin I, and in active …

The acute effects of captopril on blood pressure, renin, angiotensin, bra‐dykinin and
catecholamines were examined in patients with essential (n= 10, Group 1), accelerated (n …

1. Captopril infused into sodium-loaded dogs produced a fall in both blood pressure [117+/-
9.7 to 96.6+/-11.4 (SD) mmHg] and plasma angiotensin II [11.0+/-3.0 to 1.6+/-1.3 (SD) …

Seven patients with essential hypertension and seven patients with hypertension associated
with renal artery stenosis received captopril (SQ 14225), an inhibitor of angiotensin I …

The introduction of captopril-the first orally active inhibitor of angiotensin converting enzyme-
into clinical medicine has been an example of skilled, purposeful pharmacological …

Captopril, an orally active inhibitor of angiotensin-I-converting enzyme, was administered in
a single dose to five anephric patients who had extremely low plasma renin activities. The …