Botanical Drug Puerarin Promotes Neuronal Survival and Neurite Outgrowth against MPTP/MPP+‐Induced Toxicity via Progesterone Receptor Signaling
Y Zhao, J Zhao, X Zhang, Y Cheng… - Oxidative Medicine …, 2020 - Wiley Online Library
Background. Progesterone receptor (PR) modulates neuroprotective and regenerative
responses in Parkinson's disease and related neurological diseases. Objectives. The …
responses in Parkinson's disease and related neurological diseases. Objectives. The …
Neuroprotective effects of puerarin on 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine induced Parkinson's disease model in mice
G Zhu, X Wang, S Wu, X Li, Q Li - Phytotherapy Research, 2014 - Wiley Online Library
Puerarin, an active component of Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep
is well‐known for its anti‐oxidative and neuroprotective activities. Although anti‐Parkinson's …
is well‐known for its anti‐oxidative and neuroprotective activities. Although anti‐Parkinson's …
Puerarin suppresses MPP+/MPTP-induced oxidative stress through an Nrf2-dependent mechanism
X Li, J Zhang, X Zhang, M Dong - Food and Chemical Toxicology, 2020 - Elsevier
In this study, we hypothesized that anti-parkinsonian effect of puerarin is attributable to its
antioxidant properties via Nrf2-dependent glutathione (GSH) biosynthesis mechanism …
antioxidant properties via Nrf2-dependent glutathione (GSH) biosynthesis mechanism …
Botanical drug puerarin coordinates with nerve growth factor in the regulation of neuronal survival and neuritogenesis via activating ERK 1/2 and PI 3K/Akt signaling …
J Zhao, YY Cheng, W Fan, CB Yang… - CNS neuroscience & …, 2015 - Wiley Online Library
Aim Nerve growth factor (NGF) regulates neuronal survival and differentiation by activating
extracellular signal‐regulated‐kinases (ERK) 1/2 and phosphoinositide‐3‐kinase (PI …
extracellular signal‐regulated‐kinases (ERK) 1/2 and phosphoinositide‐3‐kinase (PI …
Puerarin protects dopaminergic neurons in Parkinson's disease models
X Zhang, J Xiong, S Liu, L Wang, J Huang, L Liu… - Neuroscience, 2014 - Elsevier
It has been acknowledged that oxidative stress, resulting in the apoptosis of dopaminergic
neurons, is a key mechanism in the pathogenesis of Parkinson's disease (PD). Puerarin …
neurons, is a key mechanism in the pathogenesis of Parkinson's disease (PD). Puerarin …
Implication of the c-Jun-NH2-terminal kinase pathway in the neuroprotective effect of puerarin against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC …
G Wang, L Zhou, Y Zhang, M Dong, X Li, J Liu… - Neuroscience Letters, 2011 - Elsevier
Apoptosis is a widely accepted component of the pathogenesis of Parkinson's disease (PD),
a debilitating neurodegenerative disorder characterized by loss of dopaminergic neurons in …
a debilitating neurodegenerative disorder characterized by loss of dopaminergic neurons in …
Progesterone exerts a neuroprotective action in a Parkinson's disease human cell model through membrane progesterone receptor α (mPRα/PAQR7)
LF Castelnovo, P Thomas - Frontiers in Endocrinology, 2023 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and current treatment options are unsatisfactory on the long term. Several …
worldwide, and current treatment options are unsatisfactory on the long term. Several …
[HTML][HTML] Neuroprotective effect of Rhodiola rosea Linn against MPTP induced cognitive impairment and oxidative stress
R Jacob, G Nalini… - Annals of neurosciences, 2013 - ncbi.nlm.nih.gov
Background Ageing and age-related neurodegenerative changes including Parkinson's
disease are characterized by an important role of reactive oxygen species. It is characterized …
disease are characterized by an important role of reactive oxygen species. It is characterized …
Curcumin and an antioxidant formulation protect C57BL/6J mice from MPTP-induced Parkinson's disease like changes: potential neuroprotection for …
G Muthian, V Mackey, K Prasad… - Journal of Parkinsonism …, 2018 - Taylor & Francis
Background: Degeneration of nigrostriatal (NS) dopamine (DA) neurons is the major
neuropathological marker of Parkinson's disease (PD). The cause for the disorder is …
neuropathological marker of Parkinson's disease (PD). The cause for the disorder is …
Ramelteon ameliorated 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in neuronal cells in a mitochondrial-dependent pathway
C Li, Y Zhang, R Liu, Y Mai - Bioengineered, 2021 - Taylor & Francis
Parkinson's disease (PD) is a common neurodegenerative disease with global health and
economic impact. 1-methyl-4-phenylpyridinium (MPP+)-induced mitochondrial dysfunction …
economic impact. 1-methyl-4-phenylpyridinium (MPP+)-induced mitochondrial dysfunction …