Reduced efficacy of cardioprotective interventions in the aged female heart, including
estrogen replacement, highlights the need for alternative therapeutics to reduce myocardial …

The mechanisms underlying the age-dependent reversal of female cardioprotection are
poorly understood and complicated by findings that estrogen replacement is ineffective at …

In adult heart, selective PKCε activation limits ischemia (I)-reperfusion (R) damage and
mimics the protection associated with ischemic preconditioning. We sought to determine …

The effects of estrogen deficiency on the loss of cardioprotection with advancing age are
complex and poorly understood. A major focus of the current study was to uncover a …

Aims Protein kinase C epsilon (PKCε) is critical for cardiac protection from ischaemia and
reperfusion (IR) injury. PKCε substrates that mediate cytoprotection reside in the …

Objective Age is a leading risk factor for the development of ischaemic heart disease and
failure. However, the efficacy of cardioprotective strategies designed to rescue the aged …

Both advancing age and estrogen loss exacerbate acute myocardial infarction in the female
heart. However, the mechanistic underpinnings of age-related differences in cell death after …

Background: Epsilon-protein kinase C (εPKC) protects the heart from ischemic injury.
However, the mechanism (s) of εPKC cardioprotection is still unclear. Identification of the …

Modest cardiac-overexpression of constitutively active PKCε (aPKCε) in transgenic mice
evokes cardioprotection against ischemia. As aPKCε interacts with mitochondrial respiratory …

Females have a lower incidence of heart failure and improved survival after myocardial
ischemia-reperfusion (I/R) compared with males. Although estrogen-suppressed …