Background Vascular endothelium plays an important role in the regulation of vascular tone.
Volatile anesthetics have been shown to attenuate endothelium-mediated relaxation in …

Background It is believed that isoflurane decreases blood pressure predominantly by
decreasing systemic vascular resistance with modest myocardial depression. Nevertheless …

Background Volatile anesthetics have been shown to have vasodilating or vasoconstricting
actions in vitro that may contribute to their cardiovascular effects in vivo. However, the …

Purpose There are several reports suggesting that volatile anesthetics alter vascular
endothelial function. We analyzed the effect of sevoflurane, a fluorinated volatile anesthetic …

Background Whether volatile anesthetics produce changes in vascular resistance and blood
flow because of direct effects on vascular tissue is unclear. Direct vasoconstricting and …

Background Propofol (2, 6-diisopropylphenol) modulates endothelium-dependent relaxation
in some arterial preparations. The effect of propofol on endothelium-dependent, prostacyclin …

Background The precise mechanisms behind the direct inhibitory action of sevoflurane on
vascular smooth muscle have not been fully elucidated. Methods Endothelium-denuded …

Background Isoflurane has been shown to directly inhibit vascular reactivity. However, less
information is available regarding its underlying mechanisms in systemic resistance arteries …

Background In small mesenteric arteries, endothelium-derived hyperpolarizing factor
(EDHF) in addition to endothelium-derived relaxing factors (EDRFs) including NO plays an …

Background The direct action of sevoflurane on systemic resistance arteries is not fully
understood. Methods Isometric force was recorded in isolated rat small mesenteric arteries …