The polyglutamine (polyQ) diseases are a class of inherited neurodegenerative diseases
including Huntington's disease, caused by the expansion of a polyQ stretch within each …

Protein aggregation is a key mechanism involved in neurodegeneration associated with
Alzheimer's, Parkinson's and Huntington's diseases. Nine diseases (including Huntington's) …

Protein misfolding is the molecular basis for several human diseases. How the primary
amino acid sequence triggers misfolding and determines the benign or toxic character of the …

Expanded polyglutamine (polyQ) stretches within endogenous proteins cause at least nine
human diseases. The structural basis of polyQ pathogenesis is the key to understanding …

The presence and aggregation of misfolded proteins has deleterious effects in the nervous
system. Among the various diseases caused by misfolded proteins is the family of the …

Polyglutamine (polyQ) expansion leads to protein aggregation and neurodegeneration in
Huntington's disease and eight other inherited neurological conditions. Expansion of the …

Abnormally expanded polyglutamine (polyQ) tracts provide a gain of toxic functions to nine
otherwise unrelated human proteins and induce progressive neurodegenerative diseases …

The formation of insoluble protein aggregates in neurons is a hallmark of neurodegenerative
diseases caused by proteins with expanded polyglutamine (polyQ) repeats. However, the …

Polyglutamine (polyQ)-expansions in differentproteins cause nine neurodegenerative
diseases. While polyQ aggregation is a key pathological hallmark of these diseases, how …

Polyglutamine (polyQ)-expansion proteins cause protein aggregation in the cytosol and
nucleus of neuronal cells, leading to neurodegenerative diseases. For example, expansion …