Abstract Chiral 1‐(o‐chlorophenyl)‐ethanols are key intermediates in the synthesis of
chemotherapeutic substances. Enantioselective reduction of o‐chloroacetophenone is a …

The asymmetric reduction of ketones is a frequently used synthesis route towards chiral
alcohols. Amongst available chemo-and biocatalysts the latter stand out in terms of product …

Whole cells of the fungus Trichothecium were found to be an effective biocatalyst for the
enantioselective bioreduction of acetophenone and its analogous compounds to their …

Escherichia coli cells co‐expressing genes coding for Candida tenuis xylose reductase and
Candida boidinii formate dehydrogenase were used for the bioreduction of o …

Background Whole cell-catalyzed biotransformation is a clear process option for the
production of chiral alcohols via enantioselective reduction of precursor ketones. A wide …

Microbial reduction of benzoylacetates is already an established part of the synthetic toolbox
to obtain chiral ethyl 3-hydroxy-3-phenylpropionate although bioreduction yields are low to …

Whole baker's yeast cells reduce t-butyl 6-chloro-3, 5-dioxohexanoate regioselectively to the
corresponding C5 hydroxy keto ester. While the (R)-alcohol was favored, the …

Amberlite XAD 2 resin enhanced the asymmetric reduction of ethyl 4-chloroacetoacetate
(ECA) to S-4-chloro-3-hydroxybutyric acid ethyl ester as catalyzed by Saccharomyces …

The increasing demand for biocatalysts in synthesizing enantiomerically pure chiral alcohols
results from the outstanding characteristics of biocatalysts in reaction, economic, and …

Background Published biocatalytic routes for accessing enantiopure 2-phenylpropanol
using oxidoreductases afforded maximal product titers of only 80 mM. Enzyme deactivation …