The use of inhaled antibiotics in the treatment of cystic fibrosis has become widespread
despite controversy in the literature as to the appropriate dosing regimen and its …

Study objective To compare drug output from a vented nebulizer (Pari LC Jet Plus) with a
traditional unvented nebulizer (Hudson 1730 T Up-Draft 11) using aerosolized tobramycin …

Forteen commercially available jet and ultrasonic nebulizers were investigated with the aim
to select the most suitable type of apparatus for the inhalation of a 10% tobramycin solution …

The inhalation of tobramycin is part of current cystic fibrosis (CF) therapy. Local therapy with
inhaled antibiotics has demonstrated improvements in pulmonary function. Current …

Recent US Phase III trials of the aerosolized delivery of tobramycin to cystic fibrosis (CF)
patients demonstrated a significant improvement in pulmonary function and in sputum …

Study objectives To determine whether tobramycin solution for inhalation (TSI) can be
administered safely and more efficiently with a new-generation aerosol device, the …

Study objective To determine whether adequate concentrations of a new formulation of
tobramycin could be delivered to the lower respiratory tract of patients with cystic fibrosis …

BACKGROUND: Jet nebulizers are commonly used to administer aerosolized tobramycin to
CF patients. The aim of this study was to assess the performance of disposable jet …

This study was performed to determine the clinical pharmacokinetics of tobramycin in six
patients with cystic fibrosis (CF) after inhalation of 600 mg. Tobramycin was administered …

The ability to predict drug deposition of inhaled drugs used in cystic fibrosis (CF) is important
if there is a need to target specific doses of drug to the lungs of individual patients. The gold …