Introduction Cardiovascular autonomic failure and neurogenic orthostatic hypotension
(nOH) are common and disabling features of Parkinson's disease (PD) and multiple system …

Abstract α-Synucleinopathies are characterized by autonomic dysfunction and motor
impairments. In the pure autonomic failure (PAF), α-synuclein (α-Syn) pathology is confined …

Parkinson's disease concept is classically restricted to a rigid-akinetic syndrome due to a
nigro-striatal dopaminergic depletion. This concept ignored the widespread extension of …

Abstract The Synuclein Meetings are a series that has been taking place every 2 years for
about 12 years. The Synuclein Meetings bring together leading experts in the field of …

Cardiovascular autonomic dysfunction, such as orthostatic hypotension consequent to
baroreflex failure and cardiac sympathetic denervation, is frequently observed in the …

Pathological aggregates of alpha-synuclein in peripheral dermal nerve fibers can be
detected in patients with idiopathic Parkinson's disease and multiple system atrophy. This …

Pure autonomic failure is a rare form of chronic autonomic failure manifesting with
neurogenic orthostatic hypotension and evidence of sympathetic noradrenergic denervation …

Cardiovascular autonomic failure is the second most common dysautonomic feature of α‐
synucleinopathies and has significant impact on daily activities and quality of life. Here we …

Neurodegenerative diseases are a heterogeneous group of disorders characterized by
gradual progressive neuronal loss in the central nervous system. Unfortunately, the …