Celiac disease (CD) is a complex immune-mediated chronic disease characterized by a
consistent inflammation of the gastrointestinal tract induced by gluten intake in genetically …

Over the past 25 years, studies led in humans have considerably improved our
understanding of celiac disease, a complex disease that is generally defined as an …

Celiac disease (CD) is a complex, immune-mediated intolerance to gliadin that develops in
genetically susceptible individuals. Although the main driving force of the disease is an …

Coeliac disease is a complex small intestinal enteropathy that develops consequently to a
breach of tolerance to gliadin, a storage protein abundantly found in cereals such as wheat …

The downstream cascade of the inflammatory response to gliadin in celiac intestinal mucosa
encompasses the early activation of the innate immunity that triggers the adaptive response …

The design and use of mouse models that reproduce key features of human diseases are
critical to advance our understanding of the pathogenesis of autoimmune diseases and to …

Celiac disease pathogenesis, in addition to immune cell component, encompasses
pathogenic events also in the duodenal epithelium. In celiac disease patients, exposure to …

In genetically predisposed individuals, dietary gluten in wheat, rye and barley triggers celiac
disease, a systemic autoimmune disorder hallmarked by an extensive small-bowel mucosal …

Background and Aims Celiac disease (CD) is a chronic inflammatory disorder of the small
intestine that is induced by dietary wheat gluten proteins (gliadins) in genetically …

This chapter provides a brief overview of current animal models for studying celiac disease,
with a focus on generating HLA transgenic mouse models. Human Leukocyte Antigen class …