Close resemblance of murine and human trials is essential to achieve the best predictive
value of animal-based translational cancer research. Kras-driven genetically engineered …

There has been substantial progress made recently in the effort to model human prostate
cancer in mice. Several mutant mice have been generated which mimic various aspects of …

Despite advances in diagnosis and treatment, gastric cancer remains the third most common
cause of cancer-related death in humans. The establishment of relevant animal models of …

Increasing evidence indicates that the heterogeneous tumor stroma supports therapy
resistance at multiple levels. Fibroblasts, particularly cancer-associated fibroblasts (CAFs) …

Prostate cancer remains a lethal disease. Preclinical cancer models that accurately
represent the tumors of the patients they are intended to help are necessary to test potential …

Animal models of human cancer have evolved in attempts to capture the complexity of the
human disease. They encompass two broad types of model, namely those in which the …

Background While it has been challenging to establish prostate cancer patient‐derived
xenografts (PDXs), with a take rate of 10‐40% and long latency time, multiple groups …

The development and optimization of high‐throughput screening methods has identified a
multitude of genetic changes associated with human disease. The use of immunodeficient …

For many decades, basic and preclinical cancer research has been based on the use of
established, commercially available cell lines, originally derived from patients' samples but …

Patient-derived xenograft (PDX) models have garnered increasing attention since the last
decade. These models are typically characterized by the implantation of fresh patient …