Owing to the molecular complexity of cancer and the cost of therapy, researchers have
begun looking to in vivo functional genomics to inform patient care. Unfortunately …

The advances in radiotherapy (3D-CRT, IMRT) have enabled high doses of radiation to be
delivered with the least possible associated toxicity. However, the persistence of cancer …

Next-generation sequencing has revealed numerous genomic alterations that induce
aberrant signaling activities in prostate cancer (PCa). Among them are pathways affecting …

Despite significant advancements in prevention and treatment, colorectal cancer (CRC)
remains the third leading cause of cancer-related deaths. Animal models have emerged as …

Androgen deprivation therapy has a central role in the treatment of advanced prostate
cancer, often causing initial tumour remission before increasing independence from signal …

Progression to metastatic disease is the primary cause of mortality in men with prostate
cancer (PCa). Mouse models which progress with spontaneous metastasis are limited. Such …

Mouse models of human cancer are valuable tools for cancer research. Although xenografts
and genetically engineered models (GEMs) possess limitations as well as advantages, each …

Here we describe the establishment and characterization of an AR+, PSMA+, ERG+,
PTEN−/−, CHD1+/− patient-derived xenograft (PDX) model termed 'C5', which has been …

Given the complexity of prostate cancer progression and metastasis, multimodalities that
target different aspects of tumor biology, for example, radiotherapy in conjunction with …

Human xenografts are created by the introduction of human prostate tissue or cells into
immunodeficient rodents. This workgroup sought to assess the strengths and limitations of …