Adaptation of tumor cells to radiotherapy induces changes that are actionable by molecular
targeted agents and immunotherapy. This report demonstrates that radiation-induced …

Xenograft models are still the backbone of translational research, but inherent weaknesses
in this model contribute to the low rates of bench-to-bed translation in cancer research. This …

Treatments involving radiation and chemotherapy alone or in combination have improved
patient survival and quality of life. However, cancers frequently evade these therapies due to …

As one of the leading causes of death from disease, cancer continues to pose a serious
threat to human health globally. Despite the development of novel therapeutic regimens and …

The Pharmacological Audit Trail (PhAT) is designed as a biomarker-driven roadmap to
support discovery and development of anticancer drugs. The PhAT outlines key questions …

Simple Summary In its early stages, colorectal cancer (CRC) is a localized tumor, but when it
metastasizes, it has dramatic consequences. Murine models in CRC research are important …

BACKGROUND In order to learn more about short‐and long‐term effects of castration
therapy, relevant model systems for prostate cancer are required. In this study, we examined …

Despite the advancement of transgenic and gene knockout animal models in the prostate
cancer research, there is still a need for utilizing xenograft models. Xenografts can be grown …

Background Whereas the role of neoadjuvant radiotherapy in rectal cancer is well-
established, the ability to discriminate between radioresistant and radiosensitive tumors …

Abstract Development of animal models that accurately recapitulate human cancer is an
ongoing challenge. This is particularly relevant in the study of osteosarcoma (OS), a highly …