Introduction Although early institution of adequate antimicrobial therapy is lifesaving in
sepsis patients, optimal antimicrobial strategy has not been established. Moreover, the …

Introduction Altered pharmacokinetics (PK) in critically ill patients can result in insufficient
serum β-lactam concentrations when standard dosages are administered. Previous studies …

Introduction In patients with severe sepsis and septic shock as cause of Intensive Care Unit
(ICU) admission, we analyze the impact on mortality of adequate antimicrobial therapy …

Background Sepsis is common, deadly, and heterogenous. Prior analyses of patients with
sepsis and septic shock in New York State showed a risk-adjusted association between …

Introduction National clinical practice guidelines have recommended specific empiric
antimicrobial regimes for patients with severe community-acquired pneumonia. However …

Introduction Sepsis is responsible for important alterations in the pharmacokinetics of
antibiotics. Continuous renal replacement therapy (CRRT), which is commonly used in …

Introduction Sepsis is a leading cause of admission to non-cardiological intensive care units
(ICUs) and the second leading cause of death among ICU patients. We present the first …

Introduction A rational use of antibiotics is of paramount importance in order to prevent the
emergence of multidrug resistant bacteria that can lead to therapeutic impasse, especially in …

Introduction Costs are one of the factors determining physicians' choice of medication to
treat patients in specific situations. However, usually only the drug acquisition costs are …

Background Clinical and biologic phenotypes of sepsis are proposed in human studies, yet
it is unknown whether prognostic or drug response phenotypes are present in animal …