[HTML][HTML] Hemagglutinin stalk-based monoclonal antibody elicits broadly reactivity against group 1 influenza A virus

J Huang, N Huang, M Fan, L Zhao, Y Luo, P Ding… - Virology Journal, 2020 - Springer
Background Influenza virus remains a continuous and severe threat to public health
worldwide, and its prevention and treatment have always been a major international issue …

An epitope on the stem region of hemagglutinin of H1N1 influenza A virus recognized by neutralizing monoclonal antibody

L Yan, H Wang, L Sun, Y Liu, J Sun, X Zhao, Y Li… - Biochemical and …, 2019 - Elsevier
Influenza A viruses are a major threat to human health and inflict a significant public health
challenge worldwide. Hemagglutinin (HA) is the main contributor to the infectivity of the virus …

Broadly reactive human monoclonal antibodies elicited following pandemic H1N1 influenza virus exposure protect mice against highly pathogenic H5N1 challenge

R Nachbagauer, D Shore, H Yang, SK Johnson… - Journal of …, 2018 - Am Soc Microbiol
Broadly cross-reactive antibodies (Abs) that recognize conserved epitopes within the
influenza virus hemagglutinin (HA) stalk domain are of particular interest for their potential …

Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin

GS Tan, PS Lee, RMB Hoffman… - Journal of …, 2014 - Am Soc Microbiol
Due to continuous changes to its antigenic regions, influenza viruses can evade immune
detection and cause a significant amount of morbidity and mortality around the world …

Generation, characterization, and protective ability of mouse monoclonal antibodies against the HA of A (H1N1) influenza virus

L Wang, F Yang, Y Xiao, B Chen, F Liu… - Journal of medical …, 2022 - Wiley Online Library
Influenza virus infections pose a continuous threat to human health. Although vaccines
function as a preventive and protective tool, they may not be effective due to antigen drift or …

Human monoclonal antibody 81.39 a effectively neutralizes emerging influenza A viruses of group 1 and 2 hemagglutinins

H Marjuki, VP Mishin, N Chai, MW Tan… - Journal of …, 2016 - Am Soc Microbiol
The pandemic threat posed by emerging zoonotic influenza A viruses necessitates
development of antiviral agents effective against various antigenic subtypes. Human …

Identification of key residues of B cell epitopes in hemagglutinin of H6 influenza A virus

Z Wan, J Gong, J Sang, W Jiang, Z Zhao… - Microbiology …, 2023 - Am Soc Microbiol
ABSTRACT H6 influenza A viruses are enzootic and genetically diverse in both domestic
poultry and wild birds, occasionally causing spillovers to mammals, including humans …

Generation and characterization of monoclonal antibodies against the hemagglutinin of H3N2 influenza A viruses

F Yang, L Zhu, F Liu, L Cheng, H Yao, N Wu, H Wu, L Li - Virus Research, 2022 - Elsevier
Seasonal influenza viruses are highly contagious, leading to 290,000–650,000 mortalities
every year globally. Among the influenza viruses, influenza A virus (H3N2) has attracted …

[HTML][HTML] Cross-reactive fc-fused single-domain antibodies to hemagglutinin stem region protect mice from group 1 influenza a virus infection

DV Voronina, DV Shcheblyakov, IA Favorskaya… - Viruses, 2022 - mdpi.com
The continued evolution of influenza viruses reduces the effectiveness of vaccination and
antiviral drugs. The identification of novel and universal agents for influenza prophylaxis and …

Human single-chain antibodies that neutralize homologous and heterologous strains and clades of influenza A virus subtype H5N1

S Maneewatch, J Thanongsaksrikul… - Antiviral …, 2009 - journals.sagepub.com
Background Human antibodies that interfere with the biological activity of haemagglutinins
(HAs) of influenza viruses have high potential as an antiviral agent. Methods Human single …