Antibacterial resistance to infectious diseases is a significant global concern for health care
organizations; along with aging populations and increasing cancer rates, it represents a …

Simple Summary In this review, we describe arginine's role as a signaling metabolite,
epigenetic regulator and mitochondrial modulator in cancer cells, and summarize recent …

Arginine, one among the 20 most common natural amino acids, has a pivotal role in cellular
physiology as it is being involved in numerous cellular metabolic and signaling pathways …

Arginine is a crucial amino acid that serves to modulate the cellular immune response
during infection. Arginine is also a common substrate for both inducible nitric oxide synthase …

Arginase is a key hydrolase in the urea cycle that hydrolyses L-arginine to urea and L-
ornithine. Increasing number of studies in recent years demonstrate that two mammalian …

Amino acid metabolism is a critical regulator of the immune response, and its modulating
becomes a promising approach in various forms of immunotherapy. Insufficient …

Streptococcus pneumoniae is auxotrophic for arginine, and molecular analysis of the
pneumococcal genome showed that the gene encoding an arginine-ornithine antiporter …

Tumor cells often exhibit specific metabolic defects due to the aberrations in oncogene‐
dependent regulatory and/or signaling pathways that distinguish them from normal cells …

Already very early, the study of microbial arginine biosynthesis and its regulation contributed
significantly to the development of new ideas and concepts. Hence, the term “repression” …

Renewed interest in the use of therapeutic enzymes combined with an improved knowledge
of cancer cell metabolism, has led to the translation of several arginine depletion strategies …