In the past decade, great interest has been shown in the role of sirtuin 1 (SIRT1) in
tumorigenesis. The published data show SIRT1 can function as both a tumor promoter and …

Abstract Sirtuin 2 (SIRT2) belongs to the sirtuins family. It exists in many tissues and organs
of the human body and regulates a wide range of biological functions. Studies have found …

Abstract Sirtuins (SIRT1–7), the mammalian homologues of the Sir2 gene in yeast, have
emerging roles in age-related diseases, such as cardiac hypertrophy, diabetes, obesity, and …

The sirtuin family has emerged as important regulators of diverse physiological and
pathological events, including life-span extension, neurodegeneration, age-related …

Sirtuin 1 (SIRT1) is an NAD+-dependent histone deacetylase which regulates many normal
physiological and pathological processes. In addition to its place in cellular energy …

Sirtuin 2 (SIRT2) is a member of the sirtuin protein family. It is a Class III histone deacetylase
(HDACs) and predominantly localized to the cytosol. SIRT2 deacetylates histones and a …

Several members of the sirtuin (SIRT) family, a highly conserved family of NAD+-dependent
enzymes, have been shown to play a critical role in both promoting and/or suppressing …

The NAD-dependent protein deacetylase sirtuin 3 (SIRT3) is an enzyme localized primarily
in the mitochondrion, where it modulates cellular functions such as nutrient metabolism, ATP …

Background Carcinogenesis is governed by a series of genetic alterations and epigenetic
changes that lead to aberrant patterns in neoplastic cells. Sirtuin-1 (SIRT1), an NAD+ …

Among the greatest challenges facing organisms is that of detecting and effectively
responding to life-threatening environmental changes that are intimately associated with …