Drugs that probe pathway efficiency and examination of the factors that alter or augment that
efficiency in pregnancy are the subjects of pharmacokinetics studies. With the Food and …

Pharmacokinetics describes the handling of a drug by the body–how the drug is absorbed,
distributed and eliminated and how these processes determine plasma concentrations of the …

Pregnancy is a complex state where changes in maternal physiology have evolved to favor
the development and growth of the placenta and the fetus. These adaptations may affect …

The only way to determine appropriate medication dosing during pregnancy is to evaluate
the pharmacokinetics and pharmacodynamics of individual medications in pregnant women …

Throughout gestation, dynamic changes in the maternal–placental–fetal unit influence the
pharmacokinetic processes of drug absorption, distribution, metabolism, and elimination …

Pharmacologic interventions play a major role in obstetrical care throughout pregnancy,
labor and delivery and the postpartum. Traditionally, obstetrical providers have utilized …

Any drug given to a pregnant woman must be considered as possibly harmful to the fetus,
since all drugs administered to the mother cross the placental membrane, although at …

Variability in drug efficacy and safety is multi-factorial. Both the pharmacokinetics (how the
body handles the drug) and the pharmacodynamics (how the body responds to the drug) …

The effects of the many biochemical and physiologic changes of pregnancy on the dose-
response relationship of drugs administered to pregnant women are poorly understood. The …

As pregnant individuals have traditionally been excluded from clinical trials, there is a gap in
knowledge at the time of drug approval regarding safety, efficacy, and appropriate dosing for …