The efficacy and safety of medications during pregnancy is highly variable and often
different than in the nonpregnant population. In part, this variability can be explained by …

In order to favor the growth and development of the fetus, the maternal-placental-fetal unit is
characterized by profound physiologic changes. These adaptations may affect maternal and …

Objective: To review the literature regarding how drug pharmacokinetics differ between
pregnant and nongravid women. Data Sources: Articles published between 1963 and 1997 …

School of Medicine University of Washington Seattle, Washington harmacokinetics deals
with rates of four basic processes that are fundamental determinants of the actions of drugs …

Pregnancy-related physiological changes can alter the absorption, distribution, metabolism
and excretion of medicines which may affect the safety and efficacy of the medicines …

Pharmacokinetic (PK) parameters describe drug absorption, distribution, metabolism, and
elimination and how these processes define plasma drug concentrations. Sex differences in …

Clinical Pharmacology During Pregnancy, Second Edition is written for clinicians,
physicians, midwives, nurses, pharmacists and other medical professionals involved in the …

Individuals vary widely in their response to drugs." This variability can be broadly
categorized as being caused by variation either in drug disposition (pharmacokin-etic …