Downregulation of Snail by DUSP1 impairs cell migration and invasion through the inactivation of JNK and ERK and is useful as a predictive factor in the prognosis of …

D Martínez-Martínez, MV Toledo Lobo, P Baquero… - Cancers, 2021 - mdpi.com
Simple Summary The role of dual specificity phosphatase 1 (DUSP1) in metastasis-
associated processes in prostate cancer and its impact on patient outcome remains to be …

[HTML][HTML] Down-regulation of dual-specificity phosphatase 5 predicts poor prognosis of patients with prostate cancer

C Cai, JY Chen, ZD Han, HC He, JH Chen… - … journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Abstract Dual-specificity phosphatase 5 (DUSP5), which specifically inactivates the
extracellular signal-regulated kinase (ERK) 1/2 within the mitogen-activated protein kinase …

[HTML][HTML] Dual specificity phosphatase 6 suppresses the growth and metastasis of prostate cancer cells

X Zhai, Q Han, Z Shan, X Qu… - Molecular medicine …, 2014 - spandidos-publications.com
Abstract Dual specificity phosphatase 6 (DUSP6) is expressed at low levels in numerous
types of human cancer. The loss of DUSP6 plays a pivotal role in tumor progression; …

DUSP22 suppresses prostate cancer proliferation by targeting the EGFR‐AR axis

HP Lin, HM Ho, CW Chang, SD Yeh, YW Su… - The FASEB …, 2019 - Wiley Online Library
Dual‐specificity phosphatases (DUSPs) regulate the activity of various downstream kinases
through serine or threonine or tyrosine dephosphorylation. Loss of function and aberrant …

[HTML][HTML] DUSP1 inhibits cell proliferation, metastasis and invasion and angiogenesis in gallbladder cancer

J Shen, S Zhou, L Shi, X Liu, H Lin, H Yu, J Tang, T Yu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
DUSP1/MKP1 is a dual-specific phosphatase that regulates MAPK activity and is known to
play a key role in tumor biology. Its function in gallbladder cancer (GBC) remains largely …

Tumor suppressor dual‐specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial‐mesenchymal transition (EMT)‐associated phenotype

VCL Wong, H Chen, JMY Ko, KW Chan… - … journal of cancer, 2012 - Wiley Online Library
Suppressive effects of DUSP6 in tumorigenesis and EMT‐associated properties were
observed. Dual‐specificity phosphatase (DUSP6) is a MAP kinase phosphatase (MKP) …

[HTML][HTML] Dual specificity phosphatase 1 expression inversely correlates with NF-κB activity and expression in prostate cancer and promotes apoptosis through a p38 …

B Gil-Araujo, MVT Lobo, M Gutiérrez-Salmerón… - Molecular …, 2014 - Elsevier
Abstract Dual specificity phosphatase 1 (DUSP1) and the transcription factor NF-κB are
implicated in prostate cancer since their expression levels are altered along this disease …

DUSP1/MKP1 promotes angiogenesis, invasion and metastasis in non-small-cell lung cancer

V Moncho-Amor, I Ibañez de Cáceres, E Bandres… - Oncogene, 2011 - nature.com
DUSP1/MKP1 is a dual-specific phosphatase that regulates MAPKs activity, with an
increasingly recognized role in tumor biology. To understand more about the involvement of …

[HTML][HTML] Dual specificity phosphatase 5 is a novel prognostic indicator for patients with advanced colorectal cancer

X Yan, L Liu, H Li, L Huang, M Yin, C Pan… - American journal of …, 2016 - ncbi.nlm.nih.gov
Abstract Dual specificity phosphatase 5 (DUSP5) is a negative regulator of Mitogen-
activated protein kinase (MAPK) signaling pathway and has recently been identified as a …

DUSP4 is involved in the enhanced proliferation and survival of DUSP4-overexpressing cancer cells

P Ratsada, N Hijiya, S Hidano, Y Tsukamoto… - Biochemical and …, 2020 - Elsevier
Abstract Dual-specificity phosphatase 4 (DUSP4), a MAP kinase phosphatase, has been
regarded as a tumor suppressor gene in several cancers. However, high-level expression of …