BACKGROUND AND OBJECTIVES: It is well known that the different cytogenetic subgroups
of acute myeloid leukemia (AML) show different age-specific frequencies. For example …

Bone marrow samples from 43 adult patients with de novo diagnosed acute myeloid
leukemia (AML)–10 acute promyelocytic leukemias (APL) with t (15; 17), four AML with inv …

Although genomic alterations drive the pathogenesis of acute myeloid leukemia (AML),
traditional classifications are largely based on morphology, and prototypic genetic founder …

During the last three decades it has become apparent that the majority of cases of acute
myeloid leukaemia (AML) are characterized by at least one of a variety of recurrent …

In routine diagnostic procedures of acute myeloid leukemia (AML), the French–American–
British (FAB) and World Health Organization (WHO) classifications both play a central role …

Complex karyotype (CK) with≥ 3 abnormalities is detected in 10–12% of patients with acute
myeloid leukemia (AML) and associated with poor prognosis. The most common …

Acquired genetic alterations such as balanced and unbalanced chromosome aberrations
and submicroscopic gene mutations and changes in gene expression strongly affect …

Accurate subclassification of leukemia and the identification of prognostic determinants are
essential to guide therapy and to improve patients' outcome. According to present standards …

Geographic heterogeneity of cytogenetic patterns in hematological malignancies has been
reported earlier, but few systematic studies of cytogenetic abnormalities in acute myeloid …

Cytogenetic analyses in acute myeloid leukemia (AML) and acute lymphoblastic leukemia
(ALL) have revealed a great number of non-random chromosome abnormalities. In many …