The proportion of the human gut bacterial community that is recalcitrant to culture remains
poorly defined. In this report, we combine high-throughput anaerobic culturing techniques …

Identifying a scalable, unbiased method for discovering which members of the human gut
microbiota influence specific physiologic, metabolic, and immunologic phenotypes remains …

Diet and nutritional status are among the most important modifiable determinants of human
health. The nutritional value of food is influenced in part by a person's gut microbial …

Human health and disease have increasingly been shown to be impacted by the gut
microbiota, and mouse models are essential for investigating these effects. However, the …

Background Human microbiota-associated (HMA) animal models relying on germ-free
recipient mice are being used to study the relationship between intestinal microbiota and …

Intestinal bacteria influence mammalian physiology, but many types of bacteria are still
uncharacterized. Moreover, reference strains of mouse gut bacteria are not easily available …

Several associations have been made between characteristics of the resident gut microbiota
and human health and disease susceptibility. Animal models provide the means to test …

Efforts to model the human gut microbiome in mice have led to important insights into the
mechanisms of host-microbe interactions. However, the model communities studied to date …

Knowledge of the spatial organization of the gut microbiota is important for understanding
the physical and molecular interactions among its members. These interactions are thought …

Efforts to probe the role of the gut microbiota in disease would benefit from a system in which
patient-derived bacterial communities can be studied at scale. We addressed this by …