Innate immune cells have complex signalling pathways for sensing pathogens and initiating
innate immune responses against infection. These pathways are tightly regulated at different …

The interaction of innate immune cells with pathogens leads to changes in gene expression
that elicit our body's first line of defense against infection. Although signaling pathways and …

The innate immune response is a rapid response to pathogens or danger signals. It is
precisely activated not only to efficiently eliminate pathogens but also to avoid excessive …

Inflammation is a fundamental biologic process that is evolutionally conserved by a germ
line code. The interplay between epigenetics and environment directs the code into …

Significance: A growing body of clinical and experimental evidence has challenged the
traditional understanding that only the adaptive immune system can mount immunological …

A fundamental property of cells of the innate immune system is their ability to elicit a
transcriptional response to a microbial stimulus or danger signal with a high degree of cell …

Pathogens have evolved strategies to promote their survival by dramatically modifying the
transcriptional profile and protein content of the host cells they infect. Modifications of the …

Immunity relies on the heterogeneity of immune cells and their ability to respond to pathogen
challenges. In the adaptive immune system, lymphocytes display a highly diverse antigen …

Recognition of pathogens by innate and adaptive immune cells instructs rapid alterations of
cellular processes to promote effective resolution of infection. To accommodate increased …

Recent successes of therapeutic intervention in chronic inflammatory diseases using
epigenetic modifiers such as histone deacetylase inhibitors and inhibitors of DNA …