Prolongation of action potential duration is the most consistent electrophysiological
abnormality in myocardium and myocytes from hypertrophied and failing hearts …

Action potential prolongation is a common finding in human heart failure and in animal
models of cardiac hypertrophy. The mechanism of action potential prolongation involves …

Action potential (AP) prolongation is a hallmark of failing myocardium. Functional
downregulation of K currents is a prominent feature of cells isolated from failing ventricles …

Objective: Heart failure in patients and in animal models is associated with action potential
prolongation of the ventricular myocytes. Changes in several membrane currents have been …

Abnormal excitability of myocardial cells may give rise to ectopic beats and initiate re-entry
around an anatomical or functional obstacle. As K+ currents control the repolarization …

Heart failure (HF) is characterized by marked prolongation of action potential duration and
reduction in cellular repolarization reserve. These changes are caused in large part by HF …

The development of novel drugs specifically directed at the ion channels underlying
particular features of cardiac action potential (AP) initiation, recovery, and refractoriness …

Heart failure (HF) produces important alterations in currents underlying cardiac
repolarization, but the transmural distribution of such changes is unknown. We therefore …

Hypokalemia is a common biochemical finding in cardiac patients and may represent a side
effect of diuretic therapy or result from endogenous activation of renin–angiotensin system …

The high incidence of sudden death in heart failure may reflect an increased propensity to
abnormal repolarization and long QT interval-related arrhythmias. If so, cells from failing …