Yersinia V–antigen exploits toll-like receptor 2 and CD14 for interleukin 10–mediated immunosuppression
A Sing, D Rost, N Tvardovskaia… - The Journal of …, 2002 - rupress.org
A characteristic of the three human-pathogenic Yersinia spp.(the plague agent Yersinia
pestis and the enteropathogenic Yersinia pseudotuberculosis and Yersinia enterocolitica) is …
pestis and the enteropathogenic Yersinia pseudotuberculosis and Yersinia enterocolitica) is …
A hypervariable N-terminal region of Yersinia LcrV determines Toll-like receptor 2-mediated IL-10 induction and mouse virulence
A Sing, D Reithmeier-Rost, K Granfors… - Proceedings of the …, 2005 - National Acad Sciences
The virulence antigen LcrV of Yersinia enterocolitica O: 8 induces IL-10 in macrophages via
Toll-like receptor 2 (TLR2). The TLR2-active region of LcrV is localized within its N-terminal …
Toll-like receptor 2 (TLR2). The TLR2-active region of LcrV is localized within its N-terminal …
Yersinia enterocolitica evasion of the host innate immune response by V antigen-induced IL-10 production of macrophages is abrogated in IL-10-deficient mice
A Sing, A Roggenkamp, AM Geiger… - The Journal of …, 2002 - journals.aai.org
The virulence-associated V Ag (LcrV) of pathogenic Yersinia species is part of the
translocation apparatus, required to deliver antihost effector proteins (Yersinia outer …
translocation apparatus, required to deliver antihost effector proteins (Yersinia outer …
Antibody against V Antigen Prevents Yop-Dependent Growth of Yersinia pestis
AV Philipovskiy, C Cowan, CR Wulff-Strobel… - Infection and …, 2005 - Am Soc Microbiol
The V antigen (LcrV) of the plague bacterium Yersinia pestis is a potent protective antigen
that is under development as a vaccine component for humans. LcrV is multifunctional. On …
that is under development as a vaccine component for humans. LcrV is multifunctional. On …
Interleukin-10 and inhibition of innate immunity to Yersiniae: roles of Yops and LcrV (V antigen)
RR Brubaker - Infection and immunity, 2003 - Am Soc Microbiol
Plague, caused by Yersinia pestis, is recognized as the most devastating acute infectious
disease experienced by humankind. This notoriety is based upon the high rate of mortality …
disease experienced by humankind. This notoriety is based upon the high rate of mortality …
Humanized TLR4/MD-2 Mice Reveal LPS Recognition Differentially Impacts Susceptibility to Yersinia pestis and Salmonella enterica
AM Hajjar, RK Ernst, ES Fortuno III, AS Brasfield… - 2012 - journals.plos.org
Although lipopolysaccharide (LPS) stimulation through the Toll-like receptor (TLR)-4/MD-2
receptor complex activates host defense against Gram-negative bacterial pathogens, how …
receptor complex activates host defense against Gram-negative bacterial pathogens, how …
Passive immunity to infection with Yersinia spp. mediated by anti-recombinant V antigen is dependent on polymorphism of V antigen
A Roggenkamp, AM Geiger, L Leitritz… - Infection and …, 1997 - Am Soc Microbiol
The V antigen is a 37-kDa secreted polypeptide encoded on the 70-kb virulence plasmid of
pathogenic Yersinia spp. Besides having regulatory functions, it is known to be a virulence …
pathogenic Yersinia spp. Besides having regulatory functions, it is known to be a virulence …
Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response
SW Montminy, N Khan, S McGrath, MJ Walkowicz… - Nature …, 2006 - nature.com
At mammalian body temperature, the plague bacillus Yersinia pestis synthesizes
lipopolysaccharide (LPS)–lipid A with poor Toll-like receptor 4 (TLR4)–stimulating activity …
lipopolysaccharide (LPS)–lipid A with poor Toll-like receptor 4 (TLR4)–stimulating activity …
Virulence Role of V Antigen of Yersinia pestis at the Bacterial Surface
KA Fields, ML Nilles, C Cowan… - Infection and immunity, 1999 - Am Soc Microbiol
Yersinia pestis, the etiologic agent of plague, secretes a set of environmentally regulated,
plasmid pCD1-encoded virulence proteins termed Yops and V antigen (LcrV) by a type III …
plasmid pCD1-encoded virulence proteins termed Yops and V antigen (LcrV) by a type III …
The V‐antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation
J Pettersson, A Holmström, J Hill, S Leary… - Molecular …, 1999 - Wiley Online Library
Type III‐mediated translocation of Yop effectors is an essential virulence mechanism of
pathogenic YersiniaLcrV is the only protein secreted by the type III secretion system that …
pathogenic YersiniaLcrV is the only protein secreted by the type III secretion system that …