[图书][B] Toxicology and epigenetics

SC Sahu - 2012 - books.google.com
Epigenetics is the study of both heritable and non-heritable changes in the regulation of
gene activity and expression that occur without an alteration in the DNA sequence. This …

[HTML][HTML] Editorial overview of the special issue on genomic toxicology epigenetics

I Rusyn, IP Pogribny - Current opinion in toxicology, 2017 - ncbi.nlm.nih.gov
This special “Genomic Toxicology: Epigenetics” issue of “Current Opinion in Toxicology”
summarizes the current state of science at the intersection of epigenetics and toxicology …

Incorporation of an epigenetic evaluation into safety assessment: What we first need to know

JI Goodman - Current opinion in toxicology, 2017 - Elsevier
The rapidly evolving field of epigenetic regulation of gene expression is having an impact
across the spectrum of biomedical research. Toxicologists have embraced this area as …

Epigenetics–relevance to drug safety science

CC Priestley, M Anderton, AT Doherty… - Toxicology …, 2012 - academic.oup.com
Epigenetics describes the study of heritable changes in gene expression that occur in the
absence of a change to the DNA sequence. Specific patterns of epigenetic signatures can …

The dynamic epigenome and its implications in toxicology

M Szyf - Toxicological Sciences, 2007 - academic.oup.com
The epigenome serves as an interface between the dynamic environment and the inherited
static genome. The epigenome is comprised of chromatin and a covalent modification of …

Frontiers in toxicogenomics–the grand challenge: to understand how the genome and epigenome interact with the toxic environment

DM Ruden - Frontiers in genetics, 2011 - frontiersin.org
A recent advance that has revitalized toxicology studies in the past couple of decades is
Frontiers in Genetics “toxicogenomics,” the study of the effects of environmental toxins on …

Mapping the epigenome—impact for toxicology

J Marlowe, SS Teo, SD Chibout, F Pognan… - Molecular, Clinical and …, 2009 - Springer
Recent advances in technological approaches for mapping and characterizing the
epigenome are generating a wealth of new opportunities for exploring the relationship …

The next innovation cycle in toxicogenomics: environmental epigenetics

SM Reamon-Buettner, V Mutschler, J Borlak - Mutation Research/Reviews …, 2008 - Elsevier
Toxicogenomics is a field that emerged from the combination of conventional toxicology with
functional genomics. In recent years, this field contributed immensely in defining adverse …

Toxicoepigenetics for risk assessment: bridging the gap between basic and regulatory science

A Le Goff, S Louvel, H Boullier… - Epigenetics Insights, 2022 - journals.sagepub.com
Toxicoepigenetics examines the health effects of environmental exposure associated with,
or mediated by, changes in the epigenome. Despite high expectations, toxicoepigenomic …

Epigenetics and chemical safety assessment

MJ LeBaron, RJ Rasoulpour, J Klapacz… - … Research/Reviews in …, 2010 - Elsevier
Epigenetics, as it pertains to biology and toxicology, can be defined as heritable changes in
gene expression that do not involve mutations and are propagated without continued …