Severe pain occurs in the context of many diseases and conditions and is a leading cause of
disability. Nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand of the N/OFQ peptide …

Chemical modifications of nociceptin/orphanin FQ (N/OFQ) peptide that result in increased
potency and resistance to degradation have recently lead to the discovery of [(pF) Phe 4 Aib …

Nociceptin/orphanin FQ (N/OFQ) is the endogenous peptide for the NOP receptors.
Depending on the doses, intrathecal administration of N/OFQ has dual actions (ie …

1-(1-Cyclooctylpiperidin-4-yl)-indolin-2-one (SR14150) and 1-(1-(2, 3, 3 a, 4, 5, 6-hexahydro-
1 H-phenalen-1-yl) piperidinl-4-yl)-indolin-2-one (SR16835) are moderately selective …

Nociceptin/orphanin FQ (NC) and its receptor (OP 4) represent a novel peptide/receptor
system which has been implicated in the regulation of various central functions, including …

Nociceptin/orphanin FQ (N/OFQ) modulates several biological functions by activating a
specific G‐protein coupled receptor (NOP). Few molecules are available that selectively …

Nociceptin/Orphanin FQ (N/OFQ) appears to contribute to the development of morphine
tolerance, as blockade of its actions will block or reverse the process. To better understand …

The heptadecapeptide nociceptin/orphanin FQ (N/OFQ) is reported to be metabolized by
aminopeptidase N and endopeptidase 24.15. In the present study, N/OFQ C-terminal …

Background and Purpose Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor agonists
display a promising analgesic profile in preclinical studies. However, supraspinal N/OFQ …

The pharmacological management of chronic pain is a major therapeutic problem. The need
of repeated treatments reduces the usefulness of classical analgesic drugs, like μ opioid …