Objective—Endothelial activation is implicated in atherogenesis and diabetes. The role of
peroxisome proliferator-activated receptor-δ (PPAR-δ) in endothelial activation remains …

Endothelium injury is a primary event in atherogenesis, which is followed by monocyte
infiltration, macrophage differentiation, and smooth muscle cell migration. Peroxisome …

Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-activated nuclear receptor
that has an essential role in adipogenesis and glucose homeostasis. PPAR-γ is expressed …

Lipid homeostasis and inflammation are key determinants in atherogenesis, exemplified by
the requirement of lipid-laden, foam cell macrophages for atherosclerotic lesion formation …

Background—Peroxisome proliferator–activated receptor-γ (PPARγ) is expressed in
atherosclerotic plaques and in endothelial cells. The possible effects of PPARγ activators on …

An early event in acute and chronic inflammation and associated diseases such as
atherosclerosis and rheumatoid arthritis is the induced expression of specific adhesion …

The activation of cells in atherosclerotic lesions leads to the release of proinflammatory
molecules and the onset of a chronic inflammatory response. Recent evidence suggests that …

Activation of the nuclear hormone receptor peroxisome proliferator-activated receptor δ
(PPARδ) has been shown to improve insulin resistance, adiposity, and plasma HDL levels …

Peroxisome proliferator-activated receptor (PPAR) α is a nuclear receptor activated by
natural ligands such as fatty acids as well as by synthetic ligands such as fibrates currently …

Peroxisome proliferator–activated receptors (PPARs) are ligand-activated transcription
factors, originally implicated in the regulation of lipid and glucose homeostasis. In addition …