Aberrant Wnt/β-catenin signaling contributes to the development of many cancers, including
glial tumorigenesis. While cross talk between the Wnt/β-catenin and PI3K/AKT signaling …

Glioma is one of the most treatment‐refractory intracranial tumors, and the aberrant
expressed Wnt/β‐catenin pathway is closely associated with glioma malignancy. In this …

Increasing evidence suggests that interplays between Wnt/β-catenin and PI3K/AKT
signaling cascades are involved in tumor development and progression. However, the exact …

Activation of the β-catenin and receptor kinase pathways occurs often in medulloblastoma,
the most common pediatric malignant brain tumor. In this study, we show that molecular …

Aberrant wnt pathway activation through cytoplasmic stabilization of β‐catenin is crucial for
the development of various human malignancies. In gliomagenesis, the role of canonical (ie …

Glioblastoma multiforme is one of the calamitous primary glial brain tumors with extensive
heterogeneity at cellular and molecular levels. While maximal surgical resection trailed by …

Increased β-catenin transcriptional activity downstream of the Wnt/Wingless signaling
pathway has been observed in many human tumors, most notably colorectal carcinomas …

Malignant gliomas are the most common type of intrinsic central nervous system (CNS)
tumors with high mortality and morbidity. β-catenin is overexpressed in human glioblastoma …

Extensive data have shown that Wnt/beta-catenin signaling is associated with various
disease pathologies, including an important role in tumorigenesis. Here, we review the …

Aberrant activation of β-catenin signaling plays an important role in human tumorigenesis.
However, molecular mechanisms behind the β-catenin signaling deregulation are mostly …